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Updated: Jun 19, 2025

Mimicking the Function of Signaling Proteins: Toward Artificial Signal Transduction Therapy
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The Role of TRAIL Signaling in Cancer: Searching for New Therapeutic Strategies

Cheng Luo1,2,3, Shan He2,3, Feng Shi2,3

  • 1Department of Pathology, National Clinical Research Center for Geriatric Disorders/Xiangya Hospital, Central South University, Changsha 410078, China.

Biology
|July 26, 2024
PubMed

Insights

Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) selectively induces cancer cell death. This review explores TRAIL

Area of Science:

  • Oncology
  • Molecular Biology
  • Immunology

Background:

  • Cancer remains a leading global cause of mortality.
  • Tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) is a key molecule in cancer research.
  • TRAIL was identified as the tenth member of the TNF superfamily in the 1990s.

Purpose of the Study:

  • To review the critical role of TRAIL in cancer biology.
  • To analyze TRAIL's mechanisms of inducing apoptosis in cancer cells.
  • To explore TRAIL's potential as a selective anticancer agent and its influence on the tumor microenvironment.

Main Methods:

  • Literature review of TRAIL's function in cancer.
  • Analysis of TRAIL's intracellular signaling pathways.
  • Examination of TRAIL's role in intercellular communication and tumor microenvironment modulation.

Main Results:

  • TRAIL induces apoptosis in malignant cells via endogenous and exogenous pathways.
  • TRAIL signaling influences cancer progression and therapeutic responses.
  • TRAIL has demonstrated potential as a selective anticancer agent.

Conclusions:

  • TRAIL plays a significant role in cancer cell apoptosis and tumor microenvironment regulation.
  • Understanding TRAIL's mechanisms can lead to the development of targeted cancer therapies.
  • Harnessing TRAIL offers prospects for precision-based cancer treatments to improve patient outcomes.
Keywords:
apoptosiscancer treatmentimmunotherapytumor microenvironmenttumor necrosis factor-related apoptosis-inducing ligand

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