Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Pneumonia IV: Management01:28

Pneumonia IV: Management

315
The treatment of pneumonia varies based on its severity and the causative pathogen. Here is a structured approach to managing pneumonia, integrating pharmaceutical and supportive care strategies.
Bacterial Pneumonia Treatment
For bacterial pneumonia, antibiotics serve as the cornerstone of therapy. Initial treatment often begins with empirical antibiotics, tailored to the anticipated causative organism and adjusted based on culture results. Key antibiotic choices include:
315
Healthcare Associated Infections II: Preventive Measures01:22

Healthcare Associated Infections II: Preventive Measures

2.6K
Essential infection prevention measures are based on the knowledge of the infection chain, the modes of transmission in healthcare settings, and the use of the best practices in all healthcare settings. Compulsory public reporting of healthcare-associated infection rates is needed to allow individuals and the community to make informed choices regarding selecting a healthcare facility.
The best practices for preventing healthcare-associated infections include hand hygiene, patient risk...
2.6K
Methods of Documentation VI: Case Management Model01:15

Methods of Documentation VI: Case Management Model

565
The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
For example, a patient with a chronic...
565
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic01:26

Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic

4.1K
Healthcare-associated infections (HAIs) occur in a healthcare facility while a person receives care for another ailment. This category also includes work-related infections among healthcare staff.
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
4.1K
Pneumonia V: Nursing management and Prevention01:30

Pneumonia V: Nursing management and Prevention

2.0K
Nursing management of pneumonia involves promoting airway patency, facilitating rest and conserving energy, encouraging fluid intake, maintaining nutrition, and educating patients.
The nurse must practice strict medical asepsis and adhere to infection control guidelines to minimize healthcare-associated infections.
Enhance airway patency
Position the patient correctly to facilitate drainage of the affected lung segments. Manual or mechanical percussion and vibration can also be employed....
2.0K
Nursing Clinical Information System01:27

Nursing Clinical Information System

765
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
765

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pharmacological and surgical predictors of postoperative healing in medication-related osteonecrosis of the jaw: A retrospective multicenter cohort study.

Bone·2026
Same author

Inhibition of cariogenic biofilms by a zinc-doped phosphate-based glass orthodontic adhesive.

BMC oral health·2026
Same author

Aromaticity-Engineered Open-Shell Radical Anions for Air-Stable Doublet Emission in N-Annulated Perylene Diimide.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Mitochondrial Metabolic Reprogramming in Colorectal Cancer-Associated Fibroblasts: An Up-to-Date Review.

Cancers·2026
Same author

Bacterial and microeukaryotic assemblage transitions during a harmful algal bloom in the Nakdong River.

FEMS microbiology ecology·2026
Same author

Synergistic effects of intermittent parathyroid hormone (1-34) and masticatory force for alveolar bone remodeling in the maxilla of dogs.

Journal of stomatology, oral and maxillofacial surgery·2026

Related Experiment Video

Updated: Jun 19, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

163

Evolving Paradigms in Sepsis Management: A Narrative Review.

Min-Ji Kim1, Eun-Joo Choi2, Eun-Jung Choi3

  • 1Department of Internal Medicine, School of Medicine, Kyungpook National University, Kyungpook National University Chilgok Hospital, Daegu 41404, Republic of Korea.

Cells
|July 26, 2024
PubMed
Summary

Sepsis treatment faces challenges due to failed clinical trials targeting inflammation and immune responses. Understanding sepsis complexity is key to developing targeted therapies for better patient outcomes.

Keywords:
hyperinflammationimmune paralysissepsis

More Related Videos

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.0K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

54.8K

Related Experiment Videos

Last Updated: Jun 19, 2025

A Data-Driven Approach to Quantifying Immune States in Sepsis
07:42

A Data-Driven Approach to Quantifying Immune States in Sepsis

Published on: February 7, 2025

163
Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression
07:30

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

10.0K
Cecal Ligation Puncture Procedure
11:53

Cecal Ligation Puncture Procedure

Published on: May 7, 2011

54.8K

Area of Science:

  • Critical Care Medicine
  • Immunology
  • Infectious Diseases

Background:

  • Sepsis is a life-threatening organ dysfunction from infection, causing significant global mortality.
  • Current treatments targeting hyperinflammation and immunosuppression have largely failed to improve sepsis outcomes.
  • There is a critical need for novel therapeutic strategies for sepsis management.

Purpose of the Study:

  • To review the development of sepsis therapeutic agents.
  • To analyze clinical trial failures in targeting hyperinflammation and immunosuppression.
  • To explore reasons for trial failures and outline current research directions.

Main Methods:

  • Literature review of clinical trials for sepsis therapeutics.
  • Analysis of strategies targeting hyperinflammation and immunosuppression.
  • Examination of research bridging theoretical advancements and clinical application.

Main Results:

  • Many clinical trials targeting hyperinflammation and immunosuppression in sepsis have failed.
  • Reasons for failure include the complex, multifaceted nature of sepsis pathogenesis.
  • Personalized medicine and phenotypic categorization show promise for future sepsis therapies.

Conclusions:

  • Understanding sepsis pathogenesis is crucial for developing effective treatments.
  • Targeted and individualized therapies are needed to improve sepsis patient outcomes.
  • Future research should focus on precise treatment strategies for better sepsis management.