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Updated: Jun 19, 2025

Next Generation Sequencing for the Detection of Actionable Mutations in Solid and Liquid Tumors
Published on: September 20, 2016
KRAS Mutation Subtypes and Their Association with Other Driver Mutations in Oncogenic Pathways.
Koushik Mondal1,2, Mahesh Kumar Posa3, Revathi P Shenoy4
1Division of Basic & Translational Research, Saroj Gupta Cancer Centre & Research Institute, MG Road, Kolkata 700063, West Bengal, India.
KRAS mutations are key drivers of cancer. This study reveals common KRAS variants co-occur with other mutations like TP53, PIK3CA, and APC, impacting cancer progression and treatment.
Area of Science:
- Oncology
- Genetics
- Bioinformatics
Background:
- KRAS mutations are crucial oncogenic drivers.
- Understanding co-occurrence with other driver mutations is limited.
- KRAS interactions influence cancer hallmarks.
Purpose of the Study:
- To investigate KRAS co-mutation patterns.
- To explore correlations between KRAS and other driver mutations.
- To assess prognostic and predictive implications.
Main Methods:
- Utilized cBioPortal, TCGA, UALCAN, and UniProt databases.
- Analyzed co-occurrence of KRAS variants with other mutations.
- Examined transcript-level correlations.
Main Results:
- G12D and G12V KRAS variants co-occur with TP53 in PAAD and CRAD.
- G12C and G12V KRAS variants co-occur with LUAD.
- KRAS shows positive transcript-level correlation with PIK3CA and APC in CRAD.
Conclusions:
- KRAS co-mutations with TP53, PIK3CA, and APC are prevalent in specific cancers.
- These co-mutations may influence cancer signaling pathways.
- Identifying co-mutation patterns has significant therapeutic implications.
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