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Common Denominator of MASLD and Some Non-Communicable Diseases

Katarzyna Ferenc1, Sara Jarmakiewicz-Czaja2, Aneta Sokal-Dembowska2

  • 1Institute of Medicine, Medical College of Rzeszow University, 35-959 Rzeszow, Poland.

Current Issues in Molecular Biology
|July 26, 2024
PubMed

Insights

Metabolic dysfunction-associated steatohepatitis (MASLD) shares risk factors with obesity and diabetes. Holistic attention to these interconnected conditions is crucial for prevention and patient support.

Area of Science:

  • Hepatology
  • Metabolic Disorders
  • Public Health

Background:

  • Steatohepatitis is now termed metabolic dysfunction-associated steatohepatitis (MASLD).
  • MASLD is linked to metabolic disorders, genetics, epigenetics, and environmental factors.
  • Obesity, diabetes, and cardiovascular disease share mechanisms and risks with MASLD.

Purpose of the Study:

  • To highlight the interconnectedness of MASLD with other metabolic diseases.
  • To emphasize the global health impact of these conditions.
  • To advocate for a comprehensive approach to managing MASLD and related disorders.

Main Methods:

  • Review of current understanding of MASLD etiology and risk factors.
  • Analysis of shared pathomechanisms between MASLD and metabolic diseases.
  • Examination of the bidirectional relationship between MASLD and chronic diseases.

Main Results:

  • MASLD pathogenesis involves metabolic, genetic, epigenetic, and environmental influences.
  • A significant bidirectional relationship exists between MASLD and chronic diseases like diabetes and cardiovascular disease.
  • These conditions pose a global health challenge, impacting quality of life and mortality.

Conclusions:

  • Recognizing MASLD and associated conditions as a unified public health problem is essential.
  • A holistic strategy is needed for the prevention, treatment, and support of patients with MASLD and related metabolic disorders.
  • Integrated management can improve patient outcomes and reduce disease incidence.
Keywords:
cardiovascular diseasesdiabetesliver cancerobesitysteatotic liver disease

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