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Related Experiment Video

Updated: Jun 19, 2025

Focal Laser Ablation of Prostate Cancer: An Office Procedure
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Salvage High-Intensity Focused Ultrasound for Prostate Cancer after Radiation Failure: A Narrative Review.

Sina Sobhani1, Anosh Dadabhoy1, Alireza Ghoreifi1

  • 1Institute of Urology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA 90089, USA.

Current Oncology (Toronto, Ont.)
|July 26, 2024
PubMed
Summary

Salvage high-intensity focused ultrasound (HIFU) offers promising outcomes for localized prostate cancer recurrence after radiation therapy. This less-invasive focal therapy shows a 5-year survival rate of 85% for select patients.

Keywords:
(MeSH) salvage therapycancer recurrencehigh-intensity focused ultrasoundminimally invasive surgical proceduresprostate cancerradiotherapy

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Area of Science:

  • Oncology
  • Urology

Background:

  • Localized prostate cancer has multiple treatment options, including radical prostatectomy and radiotherapy.
  • Focal therapies like high-intensity focused ultrasound (HIFU) and cryotherapy are emerging as less-invasive alternatives.
  • Optimal salvage treatment for radiation-recurrent prostate cancer lacks consensus due to limited robust data.

Purpose of the Study:

  • To review available prospective and retrospective data on salvage HIFU after radiation therapy for prostate cancer.
  • To evaluate the efficacy and outcomes of salvage HIFU in patients with biochemical recurrence post-radiotherapy.

Main Methods:

  • Narrative review of published literature.
  • Analysis of prospective and retrospective studies on salvage HIFU for radio-recurrent prostate cancer.

Main Results:

  • Salvage HIFU demonstrates promising oncological outcomes for radio-recurrent prostate cancer.
  • An overall 5-year survival rate of approximately 85% was observed.
  • Incontinence rates were around 30%, varying by patient risk group and study definitions.

Conclusions:

  • Salvage HIFU is an effective focal therapy for select patients with biochemical recurrence of prostate cancer after radiation.
  • Further research and randomized controlled trials are needed to establish definitive treatment guidelines.