Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Bone Structure01:55

Bone Structure

Within the skeletal system, the structure of a bone, or osseous tissue, can be exemplified in a long bone, like the femur, where there are two types of osseous tissue: cortical and cancellous.
Bone Remodeling01:40

Bone Remodeling

Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
The Bone Matrix01:18

The Bone Matrix

Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in acid or...
Spongy Bone01:09

Spongy Bone

All bones comprise an outer layer of compact bone, and an interior made up of spongy bone tissue, also called cancellous or trabecular bone. In long bones, spongy bone tissue is mainly found in the interior of the epiphyses (broad ends of the bone).
Spongy bone is more porous, and less dense compared to compact bone. It is composed of concentric lamellae that are arranged irregularly to form the trabecular network. In some bones, the spaces between trabeculae contain red marrow, where...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Paired CycleGAN-based virtual staining for 3D X-ray histology of bone-implant systems.

Journal of synchrotron radiation·2026
Same author

A proof-of-concept study of an albumin-based bilayered scaffold for cartilage regeneration.

Materials today. Bio·2026
Same author

Integrated control of a nanoindenter and X-ray nanodiffraction for automated in situ nanomechanical studies.

Journal of synchrotron radiation·2026
Same author

A Versatile Synthesis Approach and Interface Characterization of t‑ZnO@Metal Hydroxide/Oxide Heterostructures.

Crystal growth & design·2026
Same author

High-resolution analysis of ordered and disordered isoporous 3D nanostructures using PXCT.

Discover nano·2026
Same author

Efficient detection of deformation-induced microstructural modifications in polycrystalline micropillars using scanning X-ray nanodiffraction.

Journal of applied crystallography·2026

Related Experiment Video

Updated: Jun 26, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

10.9K

Sheep Bone Ultrastructure Analyses Reveal Differences in Bone Maturation around Mg-Based and Ti Implants.

Kamila Iskhakova1, D C Florian Wieland1, Romy Marek2

  • 1Institute of Metallic Biomaterials, Helmholtz-Zentrum Hereon, Max-Planck-Straße 1, 21502 Geesthach, Germany.

Journal of Functional Biomaterials
|July 26, 2024
PubMed
Summary

Magnesium alloy implants, like ZX00, show altered bone ultrastructure and reduced stiffness compared to titanium. Further research is needed to understand magnesium ion incorporation and bone remodeling effects.

Keywords:
biodegradable magnesium implantsbone ultrastructurebone–implant interface

More Related Videos

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

15.5K
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

725

Related Experiment Videos

Last Updated: Jun 26, 2026

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo
12:19

Multi-Scale Modification of Metallic Implants With Pore Gradients, Polyelectrolytes and Their Indirect Monitoring In vivo

Published on: July 1, 2013

10.9K
An Improved Mechanical Testing Method to Assess Bone-implant Anchorage
11:51

An Improved Mechanical Testing Method to Assess Bone-implant Anchorage

Published on: February 10, 2014

15.5K
Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis
02:08

Surgical Bone Implantation Technique for Rat Tibia Models of Diabetes and Osteoporosis

Published on: July 5, 2024

725

Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Materials Science

Background:

  • Magnesium alloys offer tunable degradation and bone-like mechanical properties for bone fracture treatment.
  • ZX00 (Mg-0.45Zn-0.45Ca) exhibits suitable degradation and osseointegration, but its impact on bone ultrastructure is not fully understood.
  • Bone's hierarchical structure, including ultrastructure, dictates local mechanical responses.

Purpose of the Study:

  • To conduct the first comparative analysis of bone ultrastructure around ZX00 and titanium (Ti) implants.
  • To investigate the effects of implant degradation on bone mineralization and mechanical properties.
  • To elucidate the impact of magnesium (Mg) ion incorporation on bone healing and remodeling.

Main Methods:

  • High-spatial-resolution analysis of bone ultrastructure around ZX00 and Ti implants at 6, 12, and 24 weeks.
  • Investigation of bone mineralization using X-ray diffraction (XRD) to assess lattice spacing and crystallite size.
  • Correlative indentation and strain mapping via scanning XRD to evaluate local mechanical properties.

Main Results:

  • A significant decrease in (002) Bragg's peak lattice spacing near ZX00 implants compared to Ti, indicating altered mineralization.
  • Reduced hydroxyapatite platelet thickness and osteon density observed closer to the ZX00 implant interface.
  • Ti implants showed higher bone stiffness and faster mechanical adaptation than ZX00 implants.

Conclusions:

  • Results suggest Mg2+ ion incorporation into the bone ultrastructure around ZX00 implants.
  • Bone exhibits lower remodeling and stiffness in the presence of ZX00 implants compared to Ti implants.
  • Understanding these ultrastructural changes is crucial for optimizing biodegradable magnesium alloy implants for bone regeneration.