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Related Experiment Video

Updated: Jun 19, 2025

Calvarial Model of Bone Augmentation in Rabbit for Assessment of Bone Growth and Neovascularization in Bone Substitution Materials
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Osteoproductivity of Injectable Bone Grafts with and without Ostrich Eggshell Membrane Protein in Rabbit Femur.

Ziya Ozan Cengiz1, Ercan Durmus1, Ilhami Celik2

  • 1Oral and Maxillofacial Department, Faculty of Dentistry, Selcuk University, Konya 42250, Turkey.

Journal of Functional Biomaterials
|July 26, 2024
PubMed
Summary

Novel injectable bone grafts containing ostrich eggshell membrane protein show promising biocompatibility and osseointegration, enhancing new bone formation around dental implants in rabbit femurs.

Keywords:
bone graft materialdental implanteggshell powder

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Area of Science:

  • Biomaterials Science
  • Orthopedic Research
  • Dental Implantology

Background:

  • Evaluating novel injectable bone grafts for dental implant osseointegration.
  • Assessing biocompatibility and osteoproductivity of ostrich eggshell components.

Purpose of the Study:

  • To evaluate the biocompatibility and osseointegration of dental implants using novel injectable bone grafts.
  • To compare grafts with and without ostrich eggshell particles and membrane protein.

Main Methods:

  • Utilized sixteen New Zealand rabbits with surgically created femur bone defects.
  • Dental implants were placed adjacent to defects filled with two types of graft materials (with/without membrane protein).
  • Histology, histomorphometry, and micro-CT analyzed samples at 12 weeks; statistical analysis via ANOVA and Tukey's tests.

Main Results:

  • Grafts with membrane protein (MP+) and positive control (PC) showed significantly higher newly formed bone areas and bone-implant contact (BIC) than negative control (NC).
  • PC group exhibited the most unresorbed material, while MP- group showed the least.
  • PC group had the lowest connective tissue area, indicating superior integration.

Conclusions:

  • The developed injectable bone grafts are highly biocompatible and osteoproductive.
  • Ostrich eggshell membrane protein incorporation enhances osseointegration.
  • Further research is needed to explore cost-effectiveness and osteoproductive potential.