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Targeted Cancer Therapies

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

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Hydrogel Arrays Enable Increased Throughput for Screening Effects of Matrix Components and Therapeutics in 3D Tumor Models

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Published on: June 16, 2022

Stimulus-Responsive Hydrogels for Targeted Cancer Therapy.

Raghu Solanki¹, Dhiraj Bhatia¹

¹Department of Biological Sciences and Engineering, Indian Institute of Technology Gandhinagar, Palaj 382355, Gujarat, India.

Gels (Basel, Switzerland)

|July 26, 2024

Summary

Stimulus-responsive hydrogels offer innovative cancer therapy by targeting the tumor microenvironment (TME). These smart nanocarriers enhance drug delivery and reduce side effects for improved cancer treatment outcomes.

Keywords:

cancer drug delivery hydrogels stimuli-responsive

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Published on: October 7, 2016

Area of Science:

Biomedical Engineering
Materials Science
Oncology

Background:

Cancer's heterogeneity and treatment resistance necessitate advanced therapeutic strategies.
The tumor microenvironment (TME) presents unique characteristics exploitable for targeted drug delivery.
Conventional cancer therapies face limitations including side effects and recurrence.

Purpose of the Study:

To review advancements in stimulus-responsive hydrogels for cancer therapy.
To explore various stimuli-responsive mechanisms and their application in the TME.
To discuss current developments and challenges in hydrogel-based cancer treatment.

Main Methods:

Survey of recent literature on stimulus-responsive hydrogels.
Analysis of hydrogel properties and responsiveness to biological, chemical, and physical stimuli.
Examination of hydrogels' role in targeted drug delivery within the TME.

Main Results:

Stimulus-responsive hydrogels demonstrate potential for enhanced anticancer efficacy.
Hydrogels offer controlled drug release tailored to TME conditions.
Various stimuli (pH, redox, enzymes, temperature, light) can trigger hydrogel responses.

Conclusions:

Stimulus-responsive hydrogels are promising nanocarriers for targeted cancer therapy.
Further development is needed to overcome current challenges in hydrogel-based treatments.
Hydrogels offer novel perspectives for cancer treatment and other medical applications.