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Association of Abnormal Cardiac Biomarkers and Cardiovascular Complications, with Mortality in Patients with
Juan Esteban Gómez-Mesa1,2,3, Manuela Escalante2, Juan Andrés Muñoz-Ordoñez2
1Departamento de Cardiología, Fundación Valle del Lili, Cali 760032, Colombia.
Insights
In COVID-19 patients in Latin America, more positive cardiac biomarkers correlate with higher rates of heart failure and mortality. These markers can guide acute-phase treatment strategies for better outcomes.
Area of Science:
- Cardiology
- Infectious Diseases
- Clinical Research
Background:
- COVID-19 is linked to cardiac complications and poorer outcomes, often indicated by elevated cardiac biomarkers.
- Understanding the role of these biomarkers in diverse populations is crucial for managing the pandemic.
Purpose of the Study:
- To investigate the clinical significance of cardiac biomarkers in hospitalized COVID-19 patients across Latin America.
- To assess the association between cardiac biomarker levels and clinical outcomes, including heart failure and mortality.
Main Methods:
- The CARDIO COVID 19-20 Registry, a multicenter observational study, enrolled 476 hospitalized COVID-19 patients.
- Cardiac biomarkers including troponin, natriuretic peptide, and D-dimer were measured.
- Patients were categorized based on the number of positive biomarkers.
Main Results:
- A positive correlation was found between the number of elevated cardiac biomarkers and the incidence of decompensated heart failure.
- Increased mortality was directly proportional to the number of positive cardiac biomarkers.
- Patients with two positive biomarkers showed significantly higher mortality rates compared to those with one positive biomarker.
Conclusions:
- A higher burden of positive cardiac biomarkers in Latin American COVID-19 patients signifies increased cardiovascular risk and mortality.
- Cardiac biomarker assessment is vital for tailoring acute-phase treatment and improving patient management strategies.
Background:
The COVID-19 pandemic has highlighted a correlation between cardiac complications and elevated cardiac biomarkers, which are linked to poorer clinical outcomes.
Objective:
This study aims to determine the clinical impact of cardiac biomarkers in COVID-19 patients in Latin America.
Subjects And Methods:
The CARDIO COVID 19-20 Registry is a multicenter observational study across 44 hospitals in Latin America and the Caribbean. It included hospitalized COVID-19 patients (n = 476) who underwent troponin, natriuretic peptide, and D-dimer tests. Patients were grouped based on the number of positive biomarkers.
Results:
Among the 476 patients tested, 139 had one positive biomarker (Group C), 190 had two (Group B), 118 had three (Group A), and 29 had none (Group D). A directly proportional relationship was observed between the number of positive biomarkers and the incidence of decompensated heart failure. Similarly, there was a proportional relationship between the number of positive biomarkers and increased mortality. In Group B, patients with elevated troponin and natriuretic peptide and those with elevated troponin and D-dimer had 1.4 and 1.5 times higher mortality, respectively, than those with elevated natriuretic peptide and D-dimer.
Conclusions:
In Latin American COVID-19 patients, a higher number of positive cardiac biomarkers is associated with increased cardiovascular complications and mortality. These findings suggest that cardiac biomarkers should be utilized to guide acute-phase treatment strategies.
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