Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Methylphenidate in mild depression: a double-blind controlled trial.

J A Mattes

    The Journal of Clinical Psychiatry
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Extended-release physostigmine in Alzheimer disease: a multicenter, double-blind, 12-week study with dose enrichment. Physostigmine Study Group.

    Archives of general psychiatry·2000
    Same author

    Mood improvement from transcranial magnetic stimulation.

    The American journal of psychiatry·1999
    Same author

    Fluoxetine and norfluoxetine.

    The American journal of psychiatry·1998
    Same author

    Sertindole versus haloperidol for schizophrenia.

    The American journal of psychiatry·1998
    Same author

    Stroke resulting from a rapid switch from phenelzine to tranylcypromine.

    The Journal of clinical psychiatry·1998
    Same author

    Olanzapine on trial.

    The American journal of psychiatry·1998

    This study found that methylphenidate did not improve symptoms in mildly depressed outpatients. Further research is needed to determine if stimulants benefit specific subgroups of depressed patients.

    Area of Science:

    • Psychiatry and Pharmacology
    • Neuroscience of Mood Disorders

    Background:

    • Stimulant medications are sometimes considered for treating depression.
    • Evidence supporting their efficacy in major depressive disorder is limited.
    • The specific role of stimulants in depression requires further investigation.

    Purpose of the Study:

    • To review the literature on stimulant use in depression.
    • To conduct a controlled study evaluating methylphenidate's antidepressant effects.

    Main Methods:

    • A double-blind, randomized crossover study design was employed.
    • Twenty mildly depressed outpatients (Hamilton Depression Rating Scale scores 14-24) participated.
    • Methylphenidate (up to 60 mg/day) was compared against a placebo.

    Related Experiment Videos

    Main Results:

    • No significant antidepressant effect was observed with methylphenidate compared to placebo.
    • The study did not identify a beneficial effect in the studied group of depressed patients.

    Conclusions:

    • Methylphenidate demonstrated no antidepressant effect in mildly depressed outpatients.
    • The potential benefit of stimulants in specific subgroups of depressed patients remains unproven and requires further research.