Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Healthcare cost of home parenteral nutrition and intestinal transplantation for paediatric chronic intestinal failure in Singapore.

Intestinal Failure (New York, N.Y.)·2026
Same author

Infective endocarditis in children with chronic intestinal failure.

Intestinal Failure (New York, N.Y.)·2026
Same author

Condition-Specific Growth Charts for Children With Alagille Syndrome.

JAMA network open·2025
Same author

Autoimmune hepatitis in children: Guidelines of the Indian Society of Pediatric Gastroenterology, Hepatology, and Nutrition (ISPGHAN).

Hepatology international·2025
Same author

Elevated Serum Bile Acids Predict Poor Liver Outcomes in Children With Alagille Syndrome: Results From the GALA Study Group.

Liver international : official journal of the International Association for the Study of the Liver·2025
Same author

Deep phenotyping of patients with citrin deficiency in Singapore- single centre experience.

Molecular genetics and metabolism·2025

Related Experiment Video

Updated: Jun 19, 2025

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.1K

Hepatitis C Virus and Molecular Mimicry.

Lynette Goh1, Nanda Kerkar2

  • 1KK Women's and Children's Hospital, Singapore 229899, Singapore.

Pathogens (Basel, Switzerland)
|July 26, 2024
PubMed
Summary

Hepatitis C virus (HCV) uses molecular mimicry to evade immune detection, leading to persistent infection and autoimmune disorders. Understanding this mechanism is key to developing new therapies for HCV and its complications.

Keywords:
autoimmunityhepatitis Cmolecular mimicry

More Related Videos

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

11.6K
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.2K

Related Experiment Videos

Last Updated: Jun 19, 2025

A Protocol for Analyzing Hepatitis C Virus Replication
13:04

A Protocol for Analyzing Hepatitis C Virus Replication

Published on: June 26, 2014

24.1K
Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors
16:49

Two Methods of Heterokaryon Formation to Discover HCV Restriction Factors

Published on: July 16, 2012

11.6K
The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice
09:03

The CYP2D6 Animal Model: How to Induce Autoimmune Hepatitis in Mice

Published on: February 3, 2012

19.2K

Area of Science:

  • Immunology
  • Virology
  • Hepatology

Background:

  • Hepatitis C virus (HCV) establishes persistent infections in hepatocytes.
  • HCV employs molecular mimicry to evade host immune responses.
  • This viral evasion strategy contributes to diverse complications.

Purpose of the Study:

  • To review the intricate interactions between HCV and the host immune system.
  • To elucidate the role of molecular mimicry in viral persistence and pathogenesis.
  • To explore HCV's contribution to autoimmune and inflammatory disorders.

Main Methods:

  • Comprehensive literature review of studies on HCV-host immune interactions.
  • Analysis of mechanisms underlying molecular mimicry in HCV infection.
  • Examination of evidence linking HCV to autoimmune sequelae.

Main Results:

  • HCV's molecular mimicry allows it to resemble host proteins, evading immune surveillance.
  • This mimicry triggers systemic autoimmune responses, causing various complications.
  • HCV infection is associated with the development of autoimmune and inflammatory conditions.

Conclusions:

  • HCV-induced molecular mimicry is crucial for viral survival and pathogenesis.
  • Understanding these mechanisms offers insights into viral infection sequelae.
  • Targeting viral mimicry and associated autoimmunity is vital for effective HCV treatment.