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Annexin A2: A Double-Edged Sword in Pathogen Infection

Tianyu Wang1,2, Dengshuai Zhao1, Yuanhang Zhang1

  • 1Guangdong Provincial Key Laboratory of Animal Molecular Design and Precise Breeding, School of Life Science and Engineering, Foshan University, Foshan 528225, China.

Pathogens (Basel, Switzerland)
|July 26, 2024
PubMed

Insights

Annexin A2 (ANXA2) protein regulates inflammatory responses and cell apoptosis during pathogen infections. This review details ANXA2

Area of Science:

  • Molecular Biology
  • Immunology
  • Cell Biology

Background:

  • Annexin A2 (ANXA2) is a calcium- and phospholipid-binding protein involved in cellular functions.
  • ANXA2 plays a critical role in modulating host responses during pathogen infections.

Purpose of the Study:

  • To review the current research on Annexin A2's role in regulating pathogen infections.
  • To highlight ANXA2's involvement in immune modulation and host defense mechanisms.

Main Methods:

  • Literature review of studies on Annexin A2 and pathogen interactions.
  • Analysis of ANXA2's function in inflammatory and apoptotic pathways.

Main Results:

  • ANXA2 modulates nuclear factor kappa-B (NF-κB) and apoptosis signaling pathways.
  • ANXA2 influences inflammatory cell chemotaxis to infection sites.
  • ANXA2 can interact with pathogen proteins, affecting invasion and proliferation.

Conclusions:

  • Annexin A2 is a key regulator of the host response to various pathogen infections.
  • Understanding ANXA2's functions offers insights into host-pathogen interactions and potential therapeutic targets.
Keywords:
annexin A2bacteriainflammationvirus

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