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Research Progress on Micro(nano)plastic-Induced Programmed Cell Death Associated with Disease Risks.

Huanpeng Liu1, Huiqi Li1, Ting Chen1

  • 1Institute of Life Sciences & Biomedicine Collaborative Innovation Center of Zhejiang Province, College of Life and Environmental Science, Wenzhou University, Wenzhou 325035, China.

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Summary
This summary is machine-generated.

Micro(nano)plastics (MNPs) contaminate ecosystems and harm organisms, including humans. This review details how MNPs induce programmed cell death (PCD) and associated diseases, offering insights into mitigation strategies.

Keywords:
MNPsdiseasesprogrammed cell deathtargeted therapy strategies

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Area of Science:

  • Environmental Science
  • Toxicology
  • Cell Biology

Background:

  • Micro(nano)plastics (MNPs) are widespread environmental contaminants due to their persistence and pollutant adsorption.
  • MNPs enter organisms via inhalation and dermal contact, posing risks throughout food chains.
  • Evidence suggests MNPs trigger programmed cell death (PCD) and induce diseases in various organisms, including humans.

Purpose of the Study:

  • To systematically review MNP-induced PCD processes.
  • To elucidate the links between MNP-induced PCD and diseases.
  • To discuss therapeutic interventions and mitigation strategies for MNP-related health risks.

Main Methods:

  • Comprehensive literature review of recent research on MNP toxicology and PCD.
  • Analysis of experimental and in vitro studies on MNP effects on cell death pathways.
  • Synthesis of findings on MNP-induced pyroptosis, ferroptosis, autophagy, necroptosis, and apoptosis.

Main Results:

  • MNPs induce multiple forms of PCD, including pyroptosis, ferroptosis, autophagy, necroptosis, and apoptosis.
  • Specific PCD pathways are linked to various diseases caused by MNP exposure.
  • Current research offers insights into potential therapeutic interventions for MNP-induced pathologies.

Conclusions:

  • Understanding MNP-induced PCD is crucial for assessing health risks.
  • Targeted therapies may mitigate diseases stemming from MNP exposure.
  • This review serves as a reference for future toxicological research and risk management of MNPs.