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Effect of photobiomodulation on lower urinary tract dysfunction in rat cystitis model
Naoya Ishibashi1, Tomoyuki Uchiyama2,3,4, Shinichi Tao1
1Bio-Medical Engineering Group, Drug Discovery Laboratory, Teijin Institute for Bio-Medical Research, Teijin Pharma Ltd., Tokyo, Japan.
Plos One
|July 26, 2024
Summary
Photobiomodulation therapy improved urine storage issues in rats with cystitis. This treatment enhanced voiding interval and volume without negatively impacting voiding function, offering a potential new therapy for bladder hypersensitivity.
Area of Science:
- Urology
- Neurology
- Biomedical Engineering
Background:
- Cystitis causes hypersensitivity in A-delta and C fibers, leading to urinary dysfunction.
- Photobiomodulation (PBM) targets sensory nervous system activity.
Purpose of the Study:
- To evaluate PBM's effect on urinary storage and voiding functions in a rat cystitis model.
- To assess PBM's potential as a treatment for cystitis-induced bladder dysfunction.
Main Methods:
- A rat cystitis model was created using acetic acid infusion into the bladder.
- Continuous cystometry was performed under anesthesia to measure bladder pressure and voiding volume.
- 830 nm laser irradiation was applied to the L6 lumbosacral intervertebral foramen.
Main Results:
- Cystitis significantly reduced voiding interval and volume.
- Laser irradiation notably increased voiding interval (217%) and volume (192%) in cystitis model rats.
- Basal pressure, intravesical pressure, and residual urine volume were unaffected by irradiation.
Conclusions:
- Photobiomodulation may improve urine storage dysfunction in cystitis without worsening voiding function.
- PBM presents a novel therapeutic avenue for managing hypersensitivity and detrusor overactivity associated with cystitis.
