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Case report: A case of primary renal osteosarcoma
Wei Su1, Hao Fu1, Xiangming Mao2
1Department of Urology, Affiliated Nanhua Hospital, University of South China, Hengyang, China.
Medicine
|July 26, 2024
Summary
Primary renal osteosarcoma is a rare kidney cancer with poor prognosis. This case highlights a patient treated with PD-1 antibody, but outcome remained poor, underscoring the need for targeted therapies.
Area of Science:
- Oncology
- Nephrology
- Surgical Pathology
Background:
- Primary renal osteosarcoma is an exceptionally rare malignant tumor, with fewer than 30 reported cases since 1936.
- This condition is characterized by a high propensity for metastasis and a generally poor prognosis.
Observation:
- A case of a 63-year-old male with a large left kidney osteosarcoma (21 cm × 18 cm × 11 cm) invading the descending colon mesentery and abdominal wall.
- Clinical presentation included flank pain and gross hematuria, with imaging revealing a heterogeneous lesion with necrotic areas.
Findings:
- Radical nephrectomy was performed, and immunohistochemistry confirmed the diagnosis of osteosarcoma.
- Postoperative treatment involved a programmed cell death protein 1 (PD-1) antibody. Despite treatment, the patient experienced cancer-related pain and passed away 18 months post-surgery.
Implications:
- This case underscores the aggressive nature and poor prognosis of primary renal osteosarcoma.
- Future advancements in genetic testing and molecular biology may lead to the development of specific targeted therapies for this rare malignancy.
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