Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Physical activity, functional capacity, and mental health during the first postoperative month in patients undergoing ambulatory pulmonary wedge resection: a prospective observational study.

BMC pulmonary medicine·2026
Same author

A Fentanyl-Responsive Microneedle Patch for Harm Reduction.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)·2026
Same author

Albuminuria, but not eGFR, tracks diabetic retinopathy severity and retinal ischemia: population-based discovery, clinical replication, and OCTA evidence.

Frontiers in endocrinology·2026
Same author

Adjunctive ab-interno goniotomy in chronic angle-closure glaucoma: a retrospective proof-of-concept pilot study using doubly robust learning.

Frontiers in ophthalmology·2026
Same author

A mechanistic study on the repair of cadmium-induced male infertility using Yishen Tongluo formula based on network toxicology and experimental validation.

Frontiers in endocrinology·2026
Same author

Corrigendum to "a healthy lifestyle is associated with lower risk of depression in type 2 diabetes, irrespective of genetic susceptibility: A UK biobank cohort study" [J. Affect. Disord. 405 (2026) 121657, doi:10.1016/j.jad.2026.121657].

Journal of affective disorders·2026

Related Experiment Video

Updated: Jun 19, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

265

Inflammation and keratoconus: A comprehensive bidirectional Mendelian randomization analysis.

Xueyan Zhang1, Fenghua Cui, Qiaoling Wang

  • 1Department of Ophthalmology, The Jinan Second People's Hospital, Jinan, China.

Medicine
|July 26, 2024
PubMed
Summary

Inflammation plays a role in keratoconus (KC). This study found that higher levels of macrophage inflammatory protein-1β and MMP-13 may increase KC risk, while KC may affect interferon-gamma and interleukin-4 levels.

More Related Videos

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

19.9K

Related Experiment Videos

Last Updated: Jun 19, 2025

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures
04:48

Establishing a Severe Corneal Inflammation Model in Rats Based on Corneal Epithelium Curettage Combined with Corneal Sutures

Published on: November 22, 2024

265
Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry
05:53

Candidate Gene Testing in Clinical Cohort Studies with Multiplexed Genotyping and Mass Spectrometry

Published on: June 21, 2018

10.1K
Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

19.9K

Area of Science:

  • Ophthalmology
  • Immunology
  • Genetics

Background:

  • Inflammation and immune responses are increasingly linked to keratoconus (KC) development.
  • The precise causal relationship between specific inflammatory factors and KC remains undetermined.

Purpose of the Study:

  • To investigate the potential causal associations between circulating inflammatory regulators, matrix metalloproteinases (MMPs), and keratoconus (KC) using a two-way Mendelian randomization approach.

Main Methods:

  • Utilized a two-way Mendelian randomization (MR) design with instrumental variables for 41 inflammatory regulators and 12 MMPs from European ancestry GWAS.
  • Employed inverse-variance weighted, MR-Egger, and weighted median methods for causality assessment.
  • Conducted sensitivity analyses to address heterogeneity, horizontal pleiotropy, and stability.

Main Results:

  • Genetically predicted higher levels of macrophage inflammatory protein-1β (MIP-1β) and matrix metalloproteinase-13 (MMP-13) were associated with increased keratoconus risk.
  • Keratoconus was genetically associated with elevated levels of interferon-gamma (IFN-γ), interleukin-4 (IL-4), and matrix metalloproteinase-1 (MMP-1).

Conclusions:

  • Suggestive evidence supports a causal link between elevated macrophage inflammatory protein-1β and MMP-13 levels and an increased risk of keratoconus.
  • Findings indicate that keratoconus may influence the expression levels of interferon-gamma, interleukin-4, and MMP-1.