Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Clinical Applications of Epidermal Stem Cells01:19

Clinical Applications of Epidermal Stem Cells

2.7K
Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
2.7K
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Antioxidant And Immunomodulatory Polymer Vesicles For Effective Diabetic Wound Treatment Through Ros Scavenging And Immune Modulating

Antioxidant and Immunomodulatory Polymer Vesicles for Effective Diabetic Wound Treatment through ROS Scavenging and Immune Modulating

Wenqing Zhang1, Zhenghong Ge1, Yufen Xiao2

  • 1Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China.

Nano Letters
|July 26, 2024

Related Experiment Videos

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.2K
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:23

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

227
In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
06:40

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

10.9K

View abstract on PubMed

Summary
This summary is machine-generated.

This study presents a novel polymer vesicle that treats diabetic wounds by reducing oxidative stress and modulating immune responses. The antioxidant and immunomodulatory vesicle effectively healed infected diabetic wounds in mice.

Area of Science:

  • Biomaterials Science
  • Immunology
  • Wound Healing Research

Background:

  • Diabetic wounds suffer from high glucose, immune dysfunction, elevated reactive oxygen species (ROS), and delayed healing.
  • Existing treatments often fail to address the complex interplay of oxidative stress and immune imbalance in diabetic wound pathogenesis.

Purpose of the Study:

  • To develop and evaluate an antioxidant and immunomodulatory polymer vesicle for enhanced diabetic wound treatment.
  • To investigate the vesicle's efficacy in scavenging ROS and restoring immune homeostasis.

Main Methods:

  • Self-assembly of a polymer vesicle from poly(ε-caprolactone)-block-poly[lysine-stat-(lysine-mannose)-stat-tyrosine].
  • Incorporation of polytyrosine for ROS scavenging and d-mannose for immunomodulation (macrophage and Treg cell regulation).
Keywords:
Treg cellsantioxidantdiabetic woundsimmune regulation

Related Experiment Videos

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres
09:31

Sustained Administration of β-cell Mitogens to Intact Mouse Islets Ex Vivo Using Biodegradable Poly(lactic-co-glycolic acid) Microspheres

Published on: November 5, 2016

7.2K
Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management
09:23

Optimizing Extracellular Vesicle Delivery Using a Core-Sheath 3D-Bioprinted Scaffold for Chronic Wound Management

Published on: February 28, 2025

227
In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model
06:40

In Vivo Imaging of Reactive Oxygen Species in a Murine Wound Model

Published on: November 17, 2018

10.9K
  • In vivo testing in a mouse model of Staphylococcus aureus-infected diabetic wounds.

    • Main Results:

    • The polymer vesicle demonstrated significant ROS scavenging capabilities.
    • Treated mice showed a 23.7% increase in Treg cells and a 91.3% higher M2/M1 macrophage ratio.
    • Complete healing of infected diabetic wounds was achieved within 8 days.

    Conclusions:

    • This work introduces the first antioxidant and immunomodulatory polymer vesicle specifically designed for diabetic wound healing.
    • The vesicle effectively addresses ROS and immune dysregulation, offering a promising new therapeutic strategy for complex diabetic wounds.
    self-assembly
    vesicles