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  11. Vascular Endothelial Growth Factor Is Associated With Hepatocellular Carcinoma Recurrence, Independent Of Folate And Glutathione-related Antioxidant Enzymes: A Follow-up Study

Vascular endothelial growth factor is associated with hepatocellular carcinoma recurrence, independent of folate and glutathione-related antioxidant enzymes: A follow-up study

Yung-Fang Hsiao1, Shao-Bin Cheng2, Chia-Yu Lai3

  • 1Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan.

Nutrition Research (New York, N.Y.)
|July 26, 2024

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A Three-Dimensional Spheroid Model to Investigate the Tumor-Stromal Interaction in Hepatocellular Carcinoma
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View abstract on PubMed

Summary
This summary is machine-generated.

High pre-tumor-resection plasma vascular endothelial growth factor (VEGF) predicts hepatocellular carcinoma (HCC) recurrence. Folate and antioxidant capacities influence this association, highlighting their importance in HCC management.

Area of Science:

  • Oncology
  • Biochemistry
  • Medical Research

Background:

  • Hepatocellular carcinoma (HCC) recurrence is a major clinical challenge.
  • The interplay between tumor angiogenesis, specifically vascular endothelial growth factor (VEGF), and the body's antioxidant defenses (folate, glutathione [GSH]) in HCC patients remains under-explored.

Purpose of the Study:

  • To investigate the dynamic changes and interrelationships of VEGF, folate, GSH, and related antioxidant enzymes in HCC patients.
  • To determine the impact of these factors on HCC recurrence following tumor resection.

Main Methods:

  • Prospective study of 95 HCC patients undergoing tumor resection.
  • Serial measurements of plasma VEGF, serum folate, serum GSH, and plasma GPx/GR activities pre-resection and at 1 month, 1 year, and 3 years post-resection.
Keywords:
FolateHepatocellular carcinomaRecurrenceReduced glutathione

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  • Evaluation of HCC recurrence and survival status.

    • Main Results:

    • Plasma VEGF levels showed a slight decrease post-resection.
    • Serum folate and GSH concentrations, along with plasma GPx and GR activities, significantly increased post-resection and remained stable.
    • Pre-resection plasma VEGF was a significant independent predictor of HCC recurrence, even after adjusting for folate and antioxidant markers.

    Conclusions:

    • Pre-tumor-resection plasma VEGF is a potential independent biomarker for predicting HCC recurrence.
    • The predictive value of VEGF in HCC recurrence is influenced by folate and GSH-related antioxidant capacities, suggesting a complex biological interaction.
    Vascular endothelial growth factor