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Fever and aging.

D C Norman, D Grahn, T T Yoshikawa

    Journal of the American Geriatrics Society
    |December 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Fever responses to infection can be blunted in elderly patients due to impaired thermoregulation, affecting both behavioral and physiological responses. This review examines fever pathogenesis and its clinical relevance in infection.

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    Area of Science:

    • Immunology
    • Gerontology
    • Physiology

    Background:

    • Fever is a critical biologic response to infection.
    • Understanding fever pathogenesis and clinical relevance is crucial for patient care.
    • The interplay between fever and other infection responses requires further elucidation.

    Purpose of the Study:

    • To review the pathogenesis and clinical relevance of fever.
    • To summarize the interrelationship between fever and biologic responses to infection.
    • To explore potential reasons for blunted fever responses in elderly patients.

    Main Methods:

    • Literature review on fever pathogenesis.
    • Analysis of the relationship between fever and infection responses.
    • Examination of thermoregulation in the elderly.

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    Main Results:

    • Fever pathogenesis and clinical significance are complex.
    • Fever is interconnected with other biologic responses to infection.
    • Elderly individuals may exhibit blunted fever responses due to thermoregulation defects.

    Conclusions:

    • Thermoregulation abnormalities, including impaired behavioral and physiological responses, may underlie blunted fever in the elderly.
    • Further research into thermoregulation is needed to understand fever response variations.
    • Clinical awareness of altered fever patterns in the elderly is important for timely diagnosis and treatment.