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Updated: May 5, 2026

Preparation of Tumor Antigen-loaded Mature Dendritic Cells for Immunotherapy
Published on: August 1, 2013
"Boosting" tumor immunity in elderly mice by hyperactivating dendritic cells
1Graduate Program in Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, P.R. China; National Institute of Biological Sciences, Beijing, P.R. China.
Abstract:
Immunosenescence poses a significant challenge to tumor immunotherapy in elderly individuals. In this issue of Cell, Zhivaki et al. elucidate that dendritic cells "hyperactivated" by specific adjuvants elicit TH1-skewed CD4+ T cell responses in a manner contingent on the NLRP3 inflammasome, which can eliminate tumors in aged mice.
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