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Cortisol: Biosensing and detection strategies.

Sesuraj Balasamy1, Raji Atchudan2, Sandeep Arya3

  • 1Centre for Nano-Biosensors, Department of Prosthodontics and Materials Science, Saveetha Dental College and Hospitals, Saveetha Institute of Medical and Technical Sciences, Chennai 600077, Tamil Nadu, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 26, 2024
PubMed
Summary
This summary is machine-generated.

This review explores cortisol, a vital hormone impacting metabolism and immunity. It highlights advanced detection methods, particularly electrochemical immunosensing, and its role in cancer detection and treatment.

Keywords:
BiomarkersCancer treatmentCortisolImmuno-sensingSteroid hormoneStress regulation

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Area of Science:

  • Endocrinology
  • Biochemistry
  • Oncology

Background:

  • Cortisol is a key steroid hormone regulating metabolism, immune function, and stress.
  • Imbalances in cortisol levels are linked to diseases like Cushing's syndrome and Addison's disease.
  • Cortisol plays a significant role in cancer progression and treatment outcomes.

Purpose of the Study:

  • To provide a comprehensive review of cortisol.
  • To explore various cortisol detection methodologies and their applications.
  • To examine the emerging trends in cortisol's role in cancer detection and treatment.

Main Methods:

  • Review of existing literature on cortisol.
  • Discussion of various detection techniques: electrochemical, chromatographic, and immunoassay methods.
  • Exploration of advanced techniques including biomarkers, in-silico modeling, and machine learning for cortisol detection.

Main Results:

  • Electrochemical immunosensing shows high sensitivity and low detection limits for cortisol.
  • Cortisol's intricate relationship with cancer progression and treatment outcomes is detailed.
  • Innovative strategies for stress monitoring and healthcare advancement using cortisol detection are presented.

Conclusions:

  • Cortisol detection methodologies are advancing, with electrochemical immunosensing being a promising approach.
  • Understanding cortisol's role is crucial for cancer diagnosis, prognosis, and treatment.
  • Emerging technologies offer new avenues for personalized healthcare and stress management.