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Understanding natural language: Potential application of large language models to ophthalmology
Zefeng Yang1, Deming Wang1, Fengqi Zhou2
1State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou 510060, China.
Large language models (LLMs) offer advanced natural language processing for healthcare, enhancing communication between clinicians and patients. LLMs can aid in documentation, patient education, and future autonomous diagnostics.
Area of Science:
- Artificial Intelligence
- Natural Language Processing
- Deep Learning
Background:
- Large Language Models (LLMs) represent a significant advancement in AI, mimicking human language comprehension and generation.
- The transformer architecture has propelled generative AI beyond traditional pattern recognition, enabling sophisticated interactivity.
- Massive datasets and parameter expansion have endowed LLMs with capabilities like memory retention and advanced comprehension.
Purpose of the Study:
- To review the evolution and trajectory of Large Language Models (LLMs).
- To explore the potential implications of LLMs in healthcare communication for both clinicians and patients.
- To highlight the specific applications and future roles of LLMs within the ophthalmic space.
Main Methods:
- Comprehensive literature review of Large Language Models (LLMs) and their applications.
- Analysis of LLM capabilities in natural language processing and generative artificial intelligence.
- Exploration of current and potential future uses in clinical settings and patient care.
Main Results:
- LLMs demonstrate remarkable human interactivity, including memory and comprehension.
- Potential clinical applications include automated documentation, triage suggestions, and medical document summarization.
- Patient-facing uses involve condition explanation and personalized educational material development.
Conclusions:
- LLMs show significant promise for improving healthcare delivery quality, particularly in ophthalmic care.
- Future applications may extend to autonomous diagnosis and treatment with further validation.
- Addressing LLM limitations is crucial for successful real-world implementation in healthcare.

