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Related Experiment Video

Updated: Jun 19, 2025

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Beriberi following sleeve gastrectomy.

Bernard Liem1, Xin You Tai1, Faye Begeti1

  • 1Neurology Department, Oxford University Hospitals NHS Foundation Trust, Oxford, UK.

Practical Neurology
|July 26, 2024
PubMed
Summary
This summary is machine-generated.

Bariatric surgery can lead to severe thiamine deficiency, causing acute polyneuropathy. Early suspicion and prompt treatment are crucial for neurologists to prevent permanent disability in patients post-gastrectomy.

Keywords:
HISTOPATHOLOGYMETABOLIC DISEASENEUROPATHYNEUROPHYSIOLOGYPERIPHERAL NEUROPATHOLOGY

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Area of Science:

  • Neurology
  • Gastroenterology
  • Nutritional Science

Background:

  • Bariatric surgery rates are increasing due to rising obesity and cosmetic demands.
  • Nutritional deficiencies, particularly thiamine deficiency, are known complications of gastrectomy.
  • These deficiencies can lead to severe and permanent neurological damage.

Purpose of the Study:

  • To report two cases of acute, severe polyneuropathy after sleeve gastrectomy.
  • To highlight the diagnostic challenges and delayed confirmation of thiamine deficiency.
  • To emphasize the need for high clinical suspicion and prompt management of thiamine deficiency.

Main Methods:

  • Case report of two patients experiencing neurological symptoms post-sleeve gastrectomy.
  • Clinical evaluation, neurological examination, and biochemical testing for nutritional deficiencies.
  • Differential diagnosis considerations for acute polyneuropathy.

Main Results:

  • Both patients presented with acute, severe polyneuropathy following sleeve gastrectomy.
  • Thiamine deficiency was identified as the likely cause, though diagnosis was delayed.
  • Initial presentations mimicked other neurological conditions, complicating diagnosis.

Conclusions:

  • Neurologists must maintain a high index of suspicion for both central and peripheral thiamine deficiency presentations.
  • Early recognition and treatment are vital to prevent irreversible neurological disability.
  • Patients undergoing gastrectomy require routine, explicit information on the risks and signs of thiamine deficiency.