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Updated: May 3, 2026
Modified Posterior Vertebral Column Resection for Patients with Thoracolumbar Kyphotic Deformity
Published on: September 16, 2022
Preoperative Vertebral Fracture: A Prognostic Factor in Stage I-III Colorectal Cancer
Teppei Kamada1,2, Kenei Furukawa2, Junji Takahashi3,2
1Department of Surgery, International University of Health and Welfare Hospital, Nasushiobara, Japan; teppei0911show@yahoo.co.jp.
Background/Aim:
This study evaluated the prognostic impact of vertebral fractures (VFs) on the survival of patients with colorectal cancer (CRC).
Patients And Methods:
We included 299 patients with stage I-III CRC who had undergone elective surgery. The patients were divided into the VF group (n=94) and non-VF group (n=205). VFs were assessed using sagittal computed tomography image reconstruction (Th11-L5) performed preoperatively. Disease-free survival (DFS) and overall survival (OS) rates were analyzed.
Results:
The VF group had lower 5-year DFS and OS rates compared to the non-VF group (both, p<0.001). The independent predictors of DFS were carbohydrate antigen 19-9 (CA19-9) ≥37.0 ng/ml, T3/T4 disease, stage III CRC, osteopenia, and VF; for OS, CA19-9 ≥37.0 ng/ml, stage III, osteopenia, and VF. VF, compared with osteopenia, was a more significant prognostic factor for DFS and OS in patients with stage I+ II CRC (both, p<0.001).
Conclusion:
Preoperative VF was associated with worse DFS and OS following CRC resection.
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