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Crosstalk between kidney and bone: insights from CKD-MBD
Kodai Suzuki1,2, Keisuke Soeda1, Hirotaka Komaba3,4
1Division of Nephrology, Endocrinology and Metabolism, Tokai University School of Medicine, 143 Shimokasuya, Isehara, 259-1193, Japan.
Journal of Bone and Mineral Metabolism
|July 26, 2024
Summary
Chronic kidney disease (CKD) disrupts mineral balance, causing CKD-mineral and bone disorder (CKD-MBD). This review explores kidney-bone interactions in CKD-MBD pathogenesis.
Area of Science:
- Nephrology
- Endocrinology
- Bone Biology
Background:
- Kidneys regulate phosphate and calcium balance via FGF23, PTH, and 1,25D.
- CKD impairs this regulation, leading to CKD-mineral and bone disorder (CKD-MBD).
- CKD-MBD involves decreased 1,25D, elevated FGF23, secondary hyperparathyroidism, hyperphosphatemia, bone abnormalities, and calcification.
Purpose of the Study:
- To summarize recent findings on CKD-MBD.
- To explore kidney-bone interactions in the context of CKD-MBD pathogenesis.
Main Methods:
- Literature review of recent findings on CKD-MBD.
- Analysis of kidney-bone crosstalk in CKD-MBD.
Main Results:
- CKD-MBD is a complex disorder with significant implications for patient health.
- Understanding kidney-bone interactions is crucial for comprehending CKD-MBD pathogenesis.
- Renal osteodystrophy is a key manifestation, but other interactions are increasingly recognized.
Conclusions:
- Recent advances have deepened our understanding of CKD-MBD.
- Further research into kidney-bone interactions is vital for therapeutic development in CKD-MBD.
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