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Pharmacological therapies for IBS-C are designed to alleviate abdominal discomfort and enhance bowel function. In patients with IBS-C, fiber supplements may help soften stools and decrease straining, but may also lead to increased gas production and bloating. Osmotic laxatives like milk of magnesia are frequently used to soften stools and increase stool frequency in IBS-C patients. In addition, two drugs approved for use in severe IBS-C adult cases are linaclotide (Linzess) and lubiprostone...
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Updated: Jun 19, 2025

Author Spotlight: Isolation and Characterization of Equine Submucosal Enteric Glia — Implications for Preventing Postoperative Complications in Colic Surgery
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Preventing and Treating Colic: An Update.

Flavia Indrio1, Vanessa Nadia Dargenio2

  • 1Department of Experimental Medicine, Università del Salento, Lecce, Italy.

Advances in Experimental Medicine and Biology
|July 26, 2024
PubMed
Summary
This summary is machine-generated.

Infantile colic (IC) is a common newborn condition. This review explores how probiotics may help by balancing the gut microbiota in colicky infants.

Keywords:
BifidobacteriumGut-brain axisInfant colicLactobacillusMicrobiotaProbiotics

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Area of Science:

  • Gastroenterology
  • Microbiology
  • Pediatrics

Background:

  • Infantile colic (IC) is a prevalent functional gastrointestinal disorder (FGID) impacting newborns and families.
  • While generally self-limiting, IC symptoms can be concerning and rarely indicate serious underlying issues.
  • The multifactorial pathogenesis of IC involves complex infant-environment interactions, with gut microbiota emerging as a key factor.

Purpose of the Study:

  • To review commonly studied probiotics and probiotic mixtures for treating and preventing infantile colic.
  • To present recent clinical recommendations for probiotic use in infantile colic management.
  • To explore the role of gut microbiota modulation in addressing infantile colic.

Main Methods:

  • Systematic review of randomized controlled trials on probiotics for infantile colic.
  • Analysis of studies investigating the gut microbial environment in colicky versus healthy infants.
  • Synthesis of current evidence on probiotic efficacy and safety in infantile colic.

Main Results:

  • Evidence suggests differences in gut microbiota composition between colicky and healthy infants.
  • Probiotics have the potential to alter the host's microbiota and improve health outcomes.
  • Specific probiotics and mixtures show promise in managing infantile colic symptoms.

Conclusions:

  • Gut microbiota modulation via probiotics is a promising therapeutic avenue for infantile colic.
  • Further research is needed to establish optimal probiotic strains and dosages for infantile colic.
  • Probiotics may help restore balance in the intestinal microbiota of colicky newborns.