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Hidradenitis Suppurativa: New Targets and Emerging Treatments
Julia L Gao1,2, Tracey S Otto1,2, Martina L Porter1,2
1Harvard Medical School, Boston, MA, 02115, USA.
Abstract:
Hidradenitis suppurativa (HS) is a chronic inflammatory skin condition that can be challenging to treat. Biologics and targeted small molecules have become an increasingly popular area of investigation for therapeutic development for moderate-to-severe HS, though only three biologics-adalimumab, secukinumab, and bimekizumab-have received US Food and Drug Administration (FDA) or European Medicines Evaluation Agency approval for treating HS. Promising agents under investigation are targeting interleukin 17A/F, JAK/STAT pathway, interleukin 36, interleukin 1, and more.
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