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4,5-Dimethoxycanthin-6-one Inhibits Glioblastoma Stem Cell and Tumor Growth by Inhibiting TSPAN1 Interaction with

Wei Li1, Li-Jian Yang1, Yuan-Yuan Xiong2

  • 1Department of Neurosurgery, The Affiliated Changsha Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan, China.

Neurochemical Research
|July 26, 2024
PubMed
Summary

The compound 4,5-dimethoxycanthin-6-one effectively inhibits glioblastoma stem cell (GSC) growth and promotes differentiation. It targets the TSPAN1/TM4SF1 pathway, showing potential as a novel glioblastoma treatment.

Keywords:
4,5-Dimethoxycanthin-6-oneGlioblastomaGlioblastoma stem CellsTM4SF1TSPAN1

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