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Related Concept Videos

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  3. The Prognostic Role Of Perineural Invasion For Survival In Head And Neck Squamous Cell Carcinoma: A Systematic Review And Meta-analysis
  1. Home
  3. The Prognostic Role Of Perineural Invasion For Survival In Head And Neck Squamous Cell Carcinoma: A Systematic Review And Meta-analysis

Related Experiment Video

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma
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The Prognostic Role of Perineural Invasion for Survival in Head and Neck Squamous Cell Carcinoma: A Systematic Review

Zhuo-Ying Tao1, Guang Chu2, Yu-Xiong Su1

  • 1Division of Oral and Maxillofacial Surgery, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, China.

Cancers
|July 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Perineural invasion (PNI) significantly worsens survival outcomes in head and neck squamous cell carcinoma (HNSCC). This comprehensive review confirms PNI as a critical prognostic factor for patients with HNSCC.

Keywords:
head and neck squamous cell carcinomaperineural invasionprognosissurvival

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Area of Science:

  • Oncology
  • Pathology
  • Biostatistics

Background:

  • Head and neck squamous cell carcinoma (HNSCC) is a significant global health concern.
  • Prognostic factors for HNSCC survival are crucial for treatment planning and patient management.
  • The role of perineural invasion (PNI) in HNSCC prognosis requires comprehensive evaluation.

Purpose of the Study:

  • To systematically review and synthesize evidence on the predictive significance of PNI in HNSCC survival.
  • To quantify the impact of PNI on various survival outcomes in HNSCC patients.
  • To establish PNI as a prognostic biomarker in HNSCC.

Main Methods:

  • Systematic literature search across multiple databases for studies published in the last decade (Research Registry ID: reviewregistry1853).
  • Quality assessment of included studies using the Quality in Prognosis Studies tool.
  • Meta-analysis of survival data, presenting results as hazard ratios (HR) with 95% confidence intervals (CI).

    • Main Results:

    • Analysis of 74 studies involving 27,559 HNSCC patients.
    • Cumulative incidence of PNI in HNSCC was found to be 30%.
    • PNI-positive (PNI+) HNSCC patients demonstrated significantly worse overall survival (HR: 1.91), disease-specific survival (HR: 1.79), disease-free survival (HR: 1.82), and increased risks of recurrence and metastasis compared to PNI-negative (PNI-) patients.

    Conclusions:

    • Perineural invasion (PNI) is a robust and critical prognostic factor in head and neck squamous cell carcinoma (HNSCC).
    • The presence of PNI is associated with a substantially higher risk of mortality, recurrence, and distant metastasis.
    • These findings underscore the importance of identifying and considering PNI in the prognostication and management strategies for HNSCC.