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Updated: Jun 19, 2025

A Mouse Model to Investigate the Role of Cancer-Associated Fibroblasts in Tumor Growth
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Published on: December 22, 2020

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Fibroblasts Promote Resistance to KRAS Silencing in Colorectal Cancer Cells

Susana Mendonça Oliveira1,2,3,4, Patrícia Dias Carvalho1,2,5, André Serra-Roma1,2

  • 1i3S-Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Rua Alfredo Allen 208, 4200-135 Porto, Portugal.

Cancers
|July 27, 2024
PubMed
Summary

Cancer-associated fibroblasts (CAFs) can drive resistance to KRAS-targeted therapy in colorectal cancer (CRC). CAF secretomes restore cancer stem cell markers and promote tumor-promoting pathways, suggesting external factors contribute to treatment failure.

Keywords:
KRAScancer stemnesscolorectal cancerepithelial-mesenchymal transitionfibroblaststherapy resistance

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