Related Experiment Video
Updated: Jun 19, 2025
06:46
Competing-Risk Nomogram for Predicting Cancer-Specific Survival in Multiple Primary Colorectal Cancer Patients after Surgery
Published on: September 27, 2024
241
Chemotoxicity and Associated Risk Factors in Colorectal Cancer: A Systematic Review and Meta-Analysis
Claire J Han1,2, Xia Ning3, Christin E Burd4
1Center for Healthy Aging, Self-Management and Complex Care, College of Nursing, The Ohio State University, Columbus, OH 43210, USA.
Cancers
|July 27, 2024
Summary
Chemotherapy causes significant side effects in colorectal cancer patients, with nearly half experiencing moderate-to-severe toxicities. Monitoring and managing these toxicities, like gastrointestinal issues and neutropenia, is crucial for patient outcomes.
Area of Science:
- Oncology
- Clinical Pharmacology
- Cancer Research
Background:
- Colorectal cancer (CRC) patients face numerous chemotoxicities impacting treatment adherence, survival, and quality of life (QOL).
- Clinician-reported chemotoxicity predicts rehospitalization and survival in CRC.
- A comprehensive synthesis of clinician-reported chemotoxicity data is needed.
Purpose of the Study:
- To systematically review and meta-analyze the prevalence of chemotoxicity in CRC patients.
- To identify risk factors associated with chemotoxicity in CRC.
Main Methods:
- Systematic literature search conducted from 2009 to 2024.
- Inclusion of 30 studies, with 25 contributing to the meta-analysis.
- Analysis of pooled prevalences and risk factors for chemotoxicity.
Main Results:
- Overall moderate-to-severe chemotoxicity prevalence was 45.7%.
- Gastrointestinal (GI) toxicity (22.9%) and neutropenia (17.9%) were most common.
- Risk factors included malnutrition, frailty, impaired organ function, age, female sex, and aggressive chemotherapy.
Conclusions:
- Chemotherapy poses a significant burden of toxicity for CRC patients.
- Close monitoring and proactive management of chemotoxicity are essential.
- Understanding risk factors can guide personalized patient care and improve QOL.
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