Related Experiment Video

Updated: May 5, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.9K

Therapeutic Potential of Mangosteen Pericarp Extract-Loaded Liposomes against Superficial Skin Infection Caused by

Seong-Yeop Kim1, Seong-Yong Park1, Jung-Hwa Lee1

  • 1Department of Microbiology, School of Medicine, Kyungpook National University, Daegu 41944, Republic of Korea.

Antibiotics (Basel, Switzerland)
|July 27, 2024
PubMed

Insights

Mangosteen pericarp extract (MPE)-loaded liposomes show promising antibacterial activity against Staphylococcus species, effectively treating skin infections in companion animals. These liposomes offer a potential new topical treatment for pyoderma.

Area of Science:

  • Veterinary Dermatology
  • Nanotechnology in Medicine
  • Natural Product Chemistry

Background:

  • Staphylococcus species are common causes of skin infections in companion animals.
  • Alpha-mangostin (α-MG) from mangosteen pericarp exhibits antibacterial properties.
  • Developing effective topical treatments for animal pyoderma is crucial.

Purpose of the Study:

  • To investigate the antibacterial activity of α-MG-rich mangosteen pericarp extract (MPE)-loaded liposomes against Staphylococcus isolates.
  • To evaluate the therapeutic potential of these liposomes in a murine model of superficial skin infection.
  • To assess the safety and efficacy of the liposomal formulation for treating companion animal skin diseases.

Main Methods:

  • Purification of α-MG-rich MPE and complexation with gamma-cyclodextrin (γ-CD).
  • Preparation of nanoliposomes encapsulating MPE and γ-CD complexes.
  • In vitro determination of Minimum Inhibitory Concentrations (MICs) and Minimum Bactericidal Concentrations (MBCs).
  • In vivo evaluation of therapeutic efficacy in a murine skin infection model caused by S. pseudintermedius.

Main Results:

  • MPE-loaded liposomes demonstrated significant in vitro antibacterial activity against clinical Staphylococcus isolates.
  • Consistent MICs and MBCs were observed, with no activity against Gram-negative bacteria.
  • In vivo studies showed reduced bacterial load, smaller lesion sizes, and epidermal barrier reconstruction.
  • The liposomal formulation exhibited no cytotoxicity in canine progenitor epidermal keratinocyte cells.

Conclusions:

  • MPE-loaded liposomes are effective against Staphylococcus-induced skin infections in a preclinical model.
  • The liposomal formulation shows potential for developing a safe and effective topical treatment for superficial pyoderma in companion animals.
  • This approach leverages natural compounds for veterinary dermatological applications.
Keywords:
Staphylococcus speciescompanion animalsmangosteen pericarpsuperficial pyodermaα-mangostin

More Related Videos

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection09:15

A Mouse Model to Assess Innate Immune Response to Staphylococcus aureus Infection

Published on: February 28, 2019

11.6K
Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction06:19

Infecting Mice with Malassezia spp. to Study the Fungus-Host Interaction

Published on: November 6, 2019

12.7K

Related Concept Videos

The Skin Microbiota01:27

The Skin Microbiota

The human skin serves as a complex ecosystem inhabited by a diverse community of microorganisms, including bacteria, fungi, and viruses. This microbiome plays a critical role in maintaining skin health and defending against pathogenic invaders. The composition of microbial communities varies significantly across different regions of the body, influenced primarily by the local levels of moisture and sebum.Regional Variation in Skin MicrobiotaCutibacterium acnes predominantly colonizes sebaceous...
123
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
143
Clinical Significance of Antibiotic Resistance01:25

Clinical Significance of Antibiotic Resistance

Methicillin-resistant Staphylococcus aureus (MRSA) presents a critical public health threat, arising from its capacity to resist β-lactam antibiotics due to acquisition of the mecA gene within the staphylococcal cassette chromosome mec (SCCmec). This gene encodes penicillin-binding protein 2a (PBP2a), which impairs binding efficacy of methicillin and other β-lactams. MRSA has evolved into distinct clonal lineages impacting humans and animals alike, reinforcing its significance within...
90