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Comparative Analysis of Methicillin-Resistant Staphylococcus pseudintermedius Prevalence and Resistance Patterns in

Leonie Feuer1, Stefanie Katharina Frenzer2,3, Roswitha Merle2,3

  • 1Institute of Pharmacology and Toxicology, School of Veterinary Medicine, Freie Universität Berlin, Koserstraße 20, 14195 Berlin, Germany.

Antibiotics (Basel, Switzerland)
|July 27, 2024
PubMed

Insights

Methicillin-resistant Staphylococcus pseudintermedius (MRSP) is a growing concern in companion animals. This study found MRSP prevalence was higher in cats than dogs, with distinct resistance patterns necessitating tailored veterinary treatments.

Area of Science:

  • Veterinary Microbiology
  • Antimicrobial Resistance
  • Companion Animal Health

Background:

  • Methicillin-resistant Staphylococcus pseudintermedius (MRSP) poses a significant global health threat, especially in veterinary medicine.
  • The increasing antibiotic resistance in companion animals limits therapeutic options and can lead to severe infections.

Purpose of the Study:

  • To investigate antimicrobial resistance patterns and MRSP prevalence in dogs and cats in Germany.
  • To analyze MRSP resistance patterns by host species, sample type, and co-resistance.

Main Methods:

  • Analysis of 175,171 bacterial examination results from canine and feline samples submitted to a German veterinary diagnostic laboratory (2019-2021).
  • Data included samples from 3491 veterinary practices, representing 33.1% of practices in Germany.
  • Evaluation of Staphylococcus pseudintermedius isolation rates, methicillin resistance, and co-resistance patterns.

Main Results:

  • Staphylococcus pseudintermedius was isolated from 25.6% of samples, with higher prevalence in dogs (35.0%) than cats (3.6%).
  • Overall MRSP prevalence was 7.5%, but higher in feline samples (16.1%) compared to canine samples (7.1%).
  • High resistance rates to ampicillin and clindamycin were observed in S. pseudintermedius. MRSP showed significant co-resistance to clindamycin and sulfamethoxazole + trimethoprim.

Conclusions:

  • Distinct antimicrobial resistance patterns of MRSP were identified between cats and dogs.
  • The findings underscore the need for species-specific treatment strategies for MRSP infections in companion animals.
  • Continuous antimicrobial resistance surveillance is crucial for effective management and control of MRSP.
Keywords:
AMR monitoringMRSPantimicrobial resistancecompanion animalsretrospective

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