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Related Concept Videos

Aging01:26

Aging

41
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
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  11. Effect Of Young Plasma Therapy On Cognition, Oxidative Stress, Mirna-134, Bdnf, Creb, And Sirt-1 Expressions And Neuronal Survey In The Hippocampus Of Aged Ovariectomized Rats With Alzheimer's.

Effect of Young Plasma Therapy on Cognition, Oxidative Stress, miRNA-134, BDNF, CREB, and SIRT-1 Expressions and Neuronal Survey in the Hippocampus of Aged Ovariectomized Rats with Alzheimer's.

Parisa Habibi1,2, Siamak Shahidi1, Maryam Khajvand-Abedini3

  • 1Neurophysiology Research Center, Hamadan University of Medical Sciences, Hamadan 651783873, Iran.

Brain Sciences
|July 27, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

Young plasma therapy (YPT) shows promise in treating Alzheimer's disease (AD) dementia in aged rats. This non-pharmacological approach improved cognitive function and restored key protein expressions, offering an alternative to estrogen therapy.

Area of Science:

  • Neuroscience and Aging Research
  • Biomedical Therapies
  • Molecular Biology

Background:

  • Menopause is associated with an increased risk of Alzheimer's disease (AD) dementia.
  • Ovariectomized (OVX) aged rats serve as a model to study menopausal effects and AD.
  • Cognitive impairment in this model is linked to molecular changes including miR-134a regulation and reduced SIRT-1, CREB, and BDNF expression.

Purpose of the Study:

  • To investigate the efficacy of young plasma therapy (YPT) in ameliorating AD-induced dementia in aged OVX rats.
  • To compare YPT with 17β-estradiol therapy (ERT) in improving cognitive function and molecular markers.

Main Methods:

  • Aged ovariectomized rats were induced with Alzheimer's disease and treated with YPT, ERT, or served as controls.
  • Cognitive behaviors were assessed using NOR, MWM, and PAL tests.
Keywords:
AlzheimerestrogenmiR-134aovariectomy

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  • Gene and protein expressions (miR-134a, SIRT-1, CREB, BDNF) and oxidative stress markers were analyzed.

    • Main Results:

    • OVX and AD induced significant cognitive deficits, altered molecular expressions, and increased oxidative stress.
    • YPT significantly improved cognitive function and restored the expression of SIRT-1, CREB, and BDNF while down-regulating miR-134a.
    • YPT demonstrated comparable or superior effects to ERT in improving oxidative stress and molecular markers.

    Conclusions:

    • Young plasma therapy is a potential non-pharmacological treatment for AD-induced dementia in postmenopausal models.
    • YPT effectively ameliorates cognitive decline and restores neuroprotective molecular pathways.
    • Further research into YPT as a therapeutic strategy for AD is warranted.
    young plasma