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[Mutagenicity test of halopredone acetate]
The Journal of Toxicological Sciences
|August 1, 1985
Summary
Halopredone acetate (THS-201) was evaluated for mutagenicity. Studies showed no mutagenic activity in bacterial reverse mutation tests or chromosomal aberration tests in hamster cells.
Area of Science:
- Toxicology
- Genetics
Background:
- Assessing the safety of pharmaceutical compounds is crucial.
- Halopredone acetate (THS-201) is a pharmaceutical agent requiring mutagenicity evaluation.
Purpose of the Study:
- To investigate the potential mutagenic activity of halopredone acetate (THS-201).
Main Methods:
- Bacterial reverse mutation assay using Salmonella typhimurium and E. coli strains.
- In vitro chromosomal aberration test in cultured Chinese hamster lung (CHL) cells.
- Tests were conducted with and without metabolic activation.
Main Results:
- No significant increase in revertant colonies was observed in bacterial strains across various concentrations.
- No increase in chromosomal aberrations was detected in Chinese hamster cells at tested doses.
- Results were consistent with and without metabolic activation.
Conclusions:
- Halopredone acetate (THS-201) demonstrated no mutagenic activity in the conducted assays.
- The findings suggest THS-201 is not genotoxic under the tested conditions.