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Related Concept Videos

Dementia01:30

Dementia

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Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
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Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
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Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
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Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
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Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

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Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
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Diagnostic and Statistical Manual of Mental Disorders (DSM)01:27

Diagnostic and Statistical Manual of Mental Disorders (DSM)

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The Diagnostic and Statistical Manual of Mental Disorders (DSM) serves as the primary classification system for mental health disorders, providing standardized diagnostic criteria for clinicians and researchers. First published by the American Psychiatric Association (APA) in 1952, the DSM has undergone several revisions to reflect evolving psychiatric understanding. The fifth edition, DSM-5, released in 2013, introduced key updates that expanded diagnostic categories and modified diagnostic...
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Related Experiment Video

Updated: Jun 19, 2025

Symmetric Bihemispheric Postmortem Brain Cutting to Study Healthy and Pathological Brain Conditions in Humans
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Psychiatric Disease as a Potential Risk Factor for Dementia: A Narrative Review.

Dawson W Hedges1,2, Morgan Chase2, Thomas J Farrer3

  • 1The Department of Psychology, Brigham Young University, Provo, UT 84602, USA.

Brain Sciences
|July 27, 2024
PubMed
Summary

This review explores the link between psychiatric disorders and dementia risk. Some mental health conditions may increase the likelihood of developing dementia, warranting further investigation.

Keywords:
anxietyattention-deficit/hyperactivity disorderautism spectrum disorderbipolar disorderdementiadepressionincident dementianeurodegenerationobsessive–compulsive disorderpersonality disorderspersonality traitspost-traumatic stress disorderpsychiatric diseasespsychiatric disorderspsychotic disordersschizophrenia

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Area of Science:

  • Neurology
  • Psychiatry
  • Public Health

Background:

  • Dementia is a growing global health concern, projected to affect 150 million by 2050.
  • Established dementia risk factors include genetics, environment, demographics, and comorbidities like hypertension.
  • Emerging evidence suggests a connection between psychiatric disorders and the incidence of dementia.

Purpose of the Study:

  • To review existing literature on the association between various psychiatric disorders and dementia.
  • To evaluate if psychiatric conditions are potential risk factors for developing dementia.

Main Methods:

  • This study is a narrative review of published findings.
  • It specifically examines associations between dementia and bipolar disorder, depression, anxiety, PTSD, OCD, ADHD, ASD, schizophrenia, psychosis syndromes, and personality disorders/traits.

Main Results:

  • The review highlights findings suggesting possible links between several psychiatric disorders and subsequent dementia.
  • Preliminary evidence indicates that certain psychiatric disorders may act as risk factors for dementia.

Conclusions:

  • Further large-scale longitudinal studies and meta-analyses are necessary to confirm these associations.
  • Research should aim to elucidate mechanisms, identify specific risk factors within psychiatric populations, and explore the impact of psychiatric treatment on dementia risk.