Jove
Visualize
Contact Us

Related Concept Videos

JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
  1. Home
  3. Immunohistochemical Detection Of Indoleamine 2,3-dioxygenase In Spontaneous Mammary Carcinomas Of 96 Pet Rabbits.
  1. Home
  3. Immunohistochemical Detection Of Indoleamine 2,3-dioxygenase In Spontaneous Mammary Carcinomas Of 96 Pet Rabbits.

Related Experiment Video

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

36.9K

Immunohistochemical Detection of Indoleamine 2,3-Dioxygenase in Spontaneous Mammary Carcinomas of 96 Pet Rabbits.

Sandra Schöniger1, Sophie Degner2, Claudia Schandelmaier3

  • 1Discovery Life Sciences Biomarker Services GmbH, Germaniastrasse 7, 34119 Kassel, Germany.

Animals : an Open Access Journal From MDPI
|July 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Indoleamine 2,3-dioxygenase 1 (IDO1) is expressed in most pet rabbit mammary carcinomas. This finding suggests IDO1 may be a prognostic biomarker and therapeutic target in rabbits, aiding breast cancer research.

Keywords:
Oryctolagus cuniculusbreast cancer researchimmuno-oncologyimmunohistochemistryindoleamine 2,3-dioxygenase 1 (IDO1)mammary carcinomamammary glandpathologyrabbit

More Related Videos

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

8.9K
Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

5.3K

Related Experiment Videos

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland
11:13

Indirect Immunofluorescence on Frozen Sections of Mouse Mammary Gland

Published on: December 1, 2015

36.9K
In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research
08:53

In Vivo Immunofluorescence Localization for Assessment of Therapeutic and Diagnostic Antibody Biodistribution in Cancer Research

Published on: September 16, 2019

8.9K
Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody
07:36

Analyzing Tumor and Tissue Distribution of Target Antigen Specific Therapeutic Antibody

Published on: May 16, 2020

5.3K

Area of Science:

  • Veterinary Oncology
  • Immunology
  • Comparative Pathology

Background:

  • Prognostic biomarkers and treatments for pet rabbit mammary carcinomas are limited.
  • Indoleamine 2,3-dioxygenase 1 (IDO1), an immunosuppressive enzyme, is a target in human breast cancer.

Purpose of the Study:

  • To investigate the expression and prognostic significance of IDO1 in pet rabbit mammary carcinomas.
  • To assess the potential of IDO1 as a therapeutic target in rabbits.

Main Methods:

  • Retrospective immunohistochemical analysis of IDO1 in 96 rabbit mammary carcinomas.
  • Correlations assessed with mitotic count, hormone receptor status, and tumor-infiltrating lymphocytes (TILs).

Main Results:

  • 94% of carcinomas expressed IDO1; 86% had sparse TILs ('cold tumors').
  • Significant correlations found between higher IDO1 expression (>10% tumor cells), lower mitotic counts, and increased estrogen receptor expression.

    • Conclusions:

    • IDO1 expression is common in rabbit mammary carcinomas and may contribute to tumorigenesis.
    • IDO1 represents a potential prognostic biomarker and therapeutic target in pet rabbits.
    • Rabbits serve as a valuable model for breast cancer research.