Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Neurogenesis and Regeneration of Nervous Tissue01:15

Neurogenesis and Regeneration of Nervous Tissue

751
In the CNS, neurogenesis, the birth of new neurons from stem cells, is limited to the hippocampus in adults. In other regions of the brain and spinal cord, neurogenesis is almost non-existent due to inhibitory influences from neuroglia, especially oligodendrocytes, and the absence of growth-stimulating cues. The myelin produced by oligodendrocytes in the CNS inhibits neuronal regeneration. Furthermore, astrocytes proliferate rapidly after neuronal damage, forming scar tissue that physically...
751
Neurulation01:30

Neurulation

41.8K
Neurulation is the embryological process which forms the precursors of the central nervous system and occurs after gastrulation has established the three primary cell layers of the embryo: ectoderm, mesoderm, and endoderm. In humans, the majority of this system is formed via primary neurulation, in which the central portion of the ectoderm—originally appearing as a flat sheet of cells—folds upwards and inwards, sealing off to form a hollow neural tube. As development proceeds, the...
41.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Pancreatic Cancer Early Detection Biomarkers for High-Risk Individuals: Insights From the PRECEDE Consortium.

International journal of cancer·2026
Same author

Perspective in 3D mesenchymal stromal cells as tools for potential diabetes treatment.

Research in pharmaceutical sciences·2026
Same author

AI in pediatric surgery: a narrative review.

Translational pediatrics·2026
Same author

Early cellular plasticity promotes progression and dissemination in pancreatic adenocarcinoma.

Cancer metastasis reviews·2026
Same author

Nanoparticle-Based Oral Insulin Delivery: Challenges, Advances, and Future Directions.

Pharmaceutics·2025
Same author

Factors influencing primary care physicians recommending patients to use digital health technologies for self-management: A cross-sectional study across 20 countries.

The European journal of general practice·2025

Related Experiment Video

Updated: Jun 19, 2025

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
12:40

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

36.4K

The Placenta as a Source of Human Material for Neuronal Repair.

Alessia Dallatana1, Linda Cremonesi1, Francesco Pezzini1

  • 1Department of Surgical Sciences, Dentistry, Gynecology and Pediatrics, University of Verona, 37134 Verona, Italy.

Biomedicines
|July 27, 2024
PubMed
Summary

Placenta-derived mesenchymal stem cells (MSCs) offer a promising, underutilized source for neural tissue regeneration. Their secreted biomaterials, including extracellular vesicles and matrix, show significant therapeutic potential for repairing damaged neural tissues.

Keywords:
extracellular matrixextracellular vesiclesmesenchymal stem cellsneuronal differentiationplacentaregenerative medicine

More Related Videos

Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

2.6K
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

799

Related Experiment Videos

Last Updated: Jun 19, 2025

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue
12:40

Isolation and Expansion of Mesenchymal Stem/Stromal Cells Derived from Human Placenta Tissue

Published on: June 6, 2016

36.4K
Mouse In Vivo Placental Targeted CRISPR Manipulation
07:39

Mouse In Vivo Placental Targeted CRISPR Manipulation

Published on: April 14, 2023

2.6K
Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles
05:31

Author Spotlight: Modeling an Aspect of Preeclampsia in Female Mice Using Hypoxic Human Placenta-Derived Small Extracellular Vesicles

Published on: January 26, 2024

799

Area of Science:

  • Regenerative Medicine
  • Neuroscience
  • Biomaterials Science

Background:

  • Mesenchymal stem cells (MSCs) show promise for neural tissue repair, but an optimal source is lacking.
  • The therapeutic effects of MSCs involve both cell plasticity and secreted biomolecules like extracellular vesicles (EVs) and extracellular matrix (ECM).
  • Placenta-derived MSCs (P-MSCs) are an abundant and accessible source but remain understudied for neuroregeneration.

Purpose of the Study:

  • To review the existing literature on the neuroregenerative potential of P-MSC-derived biomaterials.
  • To highlight P-MSCs as a valuable, yet untapped, source for developing novel regenerative therapies for neural tissues.
  • To advocate for further research into P-MSC-derived biomaterials for clinical applications.

Main Methods:

  • Literature review of studies investigating P-MSC-derived biomaterials and their effects on neural tissue.
  • Analysis of the mechanisms underlying the neuroregenerative properties of MSC-secreted EVs and ECM.
  • Synthesis of current knowledge on P-MSC applications in neural repair.

Main Results:

  • Evidence suggests P-MSC-derived biomaterials possess neuroregenerative capabilities.
  • Secreted factors from MSCs, including EVs and ECM, contribute significantly to trophic effects.
  • P-MSCs represent a readily available and potent source for neural regenerative strategies.

Conclusions:

  • Placenta-derived MSCs and their biomaterials hold significant, underexplored potential for neural tissue repair and regeneration.
  • Further investigation into P-MSC-derived biomaterials is crucial for advancing human regenerative therapies.
  • Exploiting P-MSCs could lead to innovative treatments for neurological disorders and injuries.