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Updates on the Renin-Angiotensin-Aldosterone System and the Cardiovascular Continuum

Dana Pop1,2, Alexandra Dădârlat-Pop1,3, Raluca Tomoaia1,2

  • 14th Department of Internal Medicine, Faculty of Medicine, "Iuliu Hațieganu" University of Medicine and Pharmacy, 400347 Cluj-Napoca, Romania.

Biomedicines
|July 27, 2024
PubMed

Insights

The renin-angiotensin-aldosterone system impacts the cardiovascular continuum from risk factors to heart failure. Targeting its components may help halt disease progression.

Area of Science:

  • Cardiovascular Medicine
  • Endocrinology
  • Pharmacology

Background:

  • The cardiovascular continuum links risk factors to severe outcomes like heart failure.
  • The renin-angiotensin-aldosterone system (RAAS) is implicated across all continuum stages.
  • RAAS dysregulation contributes to atherothrombosis, ischemic heart disease, and renal failure.

Purpose of the Study:

  • To analyze the role of RAAS components in the cardiovascular continuum's pathophysiology.
  • To explore potential therapeutic targets within the RAAS for disease progression arrest.

Main Methods:

  • Review of existing literature on RAAS and cardiovascular disease.
  • Analysis of the mechanisms linking RAAS components to atherothrombosis and heart failure.
  • Examination of aldosterone, angiotensin, and their receptors' involvement.

Main Results:

  • RAAS components are central to initiating and advancing cardiovascular disease.
  • Specific enzymes, angiotensin types, receptors, and aldosterone drive pathological processes.
  • These factors contribute significantly to atherosclerosis and cardiac remodeling.

Conclusions:

  • The RAAS is a critical mediator throughout the cardiovascular continuum.
  • Targeting specific RAAS elements offers a promising strategy to interrupt disease progression.
  • Further research into RAAS modulation is warranted for cardiovascular and renal protection.

Keywords:
atrial fibrillationcardiovascular risk factorsheart failurerenin–angiotensin–aldosterone systemstroke

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