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Association of Umbilical Cord Perilipin 2 Levels with Neonatal Anthropometric Measurements in Infants of Diabetic

Kiymet Celik1, Nurten Ozkan Zarif1, Ikbal Ozen Kucukcetin2

  • 1Department Neonatology, Akdeniz University, 07070 Antalya, Turkey.

Children (Basel, Switzerland)
|July 27, 2024
PubMed

Insights

Infants of diabetic mothers (IDMs) show increased subcutaneous fat, but Perilipin 2 (PLIN2) levels are not linked to this increased adipose tissue. PLIN2 levels did correlate with IGF-2 and leptin in IDMs.

Area of Science:

  • Endocrinology
  • Metabolic Research
  • Pediatric Health

Background:

  • Perilipin 2 (PLIN2) influences lipid droplet formation and is implicated in metabolic diseases.
  • Infants of diabetic mothers (IDMs) often exhibit fetal hyperinsulinemia, leading to increased adipose tissue and macrosomia.
  • Understanding PLIN2's role in IDMs is crucial for metabolic and growth insights.

Purpose of the Study:

  • To examine the association between PLIN2 levels and anthropometric measurements in IDMs.
  • To investigate the relationship between PLIN2 levels and Insulin-like Growth Factor (IGF)-1, IGF-2, and leptin in IDMs.

Main Methods:

  • A cohort of IDMs was compared to a control group of infants born to non-diabetic mothers, matched for gestational age and sex.
  • Cord blood samples were analyzed for PLIN2, IGF-1, IGF-2, and leptin concentrations.
  • Standard anthropometric measurements were recorded at birth for all infants.

Main Results:

  • IDMs had significantly higher middle arm circumference and skinfold thickness (triceps, biceps, subscapular, suprailiac) compared to controls.
  • No significant differences were observed in birth weight, length, head circumference, or BMI between the groups.
  • While PLIN2, IGF-1, IGF-2, and leptin levels were similar between groups, PLIN2 showed a strong correlation with IGF-2 and leptin.

Conclusions:

  • Increased subcutaneous adipose tissue in IDMs was not associated with Perilipin 2 (PLIN2) levels.
  • Despite potential for macrosomia, PLIN2's direct link to adiposity in this context requires further investigation.
Abstract

Keywords:
birth weightinfant of diabetic motherleptinperilipin 2

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