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Related Concept Videos

Factors Affecting Drug Response: Overview01:21

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When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...
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The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
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Nonlinear Pharmacokinetics: Dependence of Elimination Half-Life and Dose Clearance01:23

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The elimination half-life and drug clearance of drugs following nonlinear kinetics can vary with dosage. The Michaelis-Menten parameters and drug concentration influence these factors. As the dose increases, the elimination half-life tends to lengthen, resulting in a reduction in clearance and a disproportionately larger area under the curve. The total clearance can be derived from the Michaelis-Menten equation for drugs following a one-compartment model.
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Methods of Documentation VI: Case Management Model01:15

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The case management model is a multidisciplinary approach that involves healthcare professionals from diverse disciplines, such as physicians, nurses, therapists, social workers, and pharmacists, working collaboratively to address the various needs of patients. Each healthcare professional brings unique expertise and perspectives, contributing to a more comprehensive understanding of the patient's condition and tailoring treatment plans accordingly.
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Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Polypharmacy In Children With Medical Complexity: A Cross-sectional Study In A Pediatric Palliative Care Center.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Paediatrics
  9. Infant And Child Health
  11. Polypharmacy In Children With Medical Complexity: A Cross-sectional Study In A Pediatric Palliative Care Center.

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Polypharmacy in Children with Medical Complexity: A Cross-Sectional Study in a Pediatric Palliative Care Center.

Anna Zanin1, Fernando Baratiri2, Barbara Roverato1

  • 1Palliative Care and Pain Service, Department of Women's and Children's Health, University of Padua, 35128 Padua, Italy.

Children (Basel, Switzerland)
|July 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Polypharmacy and medication burden are common in children with medical complexity (CMC), affecting over half of patients. These issues vary by primary diagnosis, highlighting the need for tailored care strategies.

Keywords:
children with medical complexitymedication burdenoff-label drug usepediatric palliative care

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Area of Science:

  • Pediatric pharmacology
  • Healthcare outcomes research

Background:

  • Children with medical complexity (CMC) frequently use multiple medications, leading to polypharmacy.
  • Polypharmacy is associated with adverse effects, medication errors, and increased caregiver burden.
  • Understanding medication patterns in CMC is crucial for improving patient care and reducing healthcare costs.

Purpose of the Study:

  • To determine the prevalence of polypharmacy and medication burden in pediatric patients with medical complexity.
  • To investigate the extent of off-label drug use and associated medication costs.
  • To analyze variations in these medication parameters based on primary diagnosis.

Main Methods:

  • A cross-sectional observational study was conducted at a Pediatric Palliative Care Center.
pediatrics
polypharmacy
  • Data were collected from 169 patients (age 0.3-23 years) via medical records and caregiver interviews.
  • Statistical analysis, including Chi-square and ANOVA tests, was used to compare medication data.

    • Main Results:

    • Polypharmacy affected 52.7% of patients, and medication burden was present in 44.4%.
    • Both polypharmacy and medication burden showed significant variation based on primary diagnosis (p < 0.001).
    • The median daily drug cost per patient was EUR 2.2, with significant subgroup differences; 34.6% of prescriptions were off-label.

    Conclusions:

    • Polypharmacy and medication burden are prevalent in the studied pediatric population with medical complexity.
    • Significant differences in medication patterns exist according to primary diagnosis.
    • These findings underscore the need for careful medication management in CMC to optimize outcomes and reduce burden.