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Bioengineered Mesenchymal Stem/Stromal Cells in Anti-Cancer Therapy: Current Trends and Future Prospects

Jesús I Gil-Chinchilla1, Agustín G Zapata2, Jose M Moraleda1,3

  • 1Hematopoietic Transplant and Cellular Therapy Unit, Instituto Murciano de Investigación Biosanitaria (IMIB) Pascual Parrilla, Virgen de la Arrixaca University Hospital, University of Murcia, 30120 Murcia, Spain.

Biomolecules
|July 27, 2024
PubMed

Insights

Mesenchymal stem/stromal cells (MSCs) show dual roles in cancer, potentially inhibiting or promoting tumor growth. Bioengineered MSCs offer promising strategies for targeted cancer therapy and drug delivery, with ongoing trials exploring their full potential.

Area of Science:

  • Cell Biology
  • Immunology
  • Oncology

Background:

  • Mesenchymal stem/stromal cells (MSCs) are utilized in advanced therapies for tissue repair and immune modulation.
  • MSCs exhibit controversial roles in cancer, capable of inhibiting proliferation but also promoting tumor growth via angiogenesis and immune evasion.
  • This duality necessitates careful application and bioengineering for effective cancer treatment.

Purpose of the Study:

  • To review advanced applications of MSCs in cancer therapy.
  • To explore bioengineering strategies enhancing MSCs' tumor targeting and therapeutic efficacy.
  • To discuss the potential of MSC-derived extracellular vesicles for drug delivery in cancer treatment.

Main Methods:

  • Review of literature on MSCs in cancer therapy.
  • Analysis of bioengineering strategies for MSCs.
  • Discussion of MSC-derived extracellular vesicles for targeted delivery.
  • Examination of ongoing clinical trials.

Main Results:

  • MSCs possess natural tumor-homing capabilities, making them suitable carriers for targeted cancer treatments.
  • Bioengineered MSCs can be optimized for enhanced anti-cancer effects and drug delivery.
  • MSC-derived extracellular vesicles show potential for improving drug delivery efficiency to cancer cells.

Conclusions:

  • Bioengineered MSCs hold significant promise for targeted solid tumor therapy and anti-cancer agent delivery.
  • Further research and clinical trials are crucial to establish MSCs as effective cancer therapeutics.
  • Nuanced application of MSCs, particularly through bioengineering, is key to harnessing their anti-cancer potential.
Keywords:
anti-cancer therapycell therapymesenchymal stem/stromal cellstargeted therapytherapeutic vehicles

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