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Clinical Applications of Epidermal Stem Cells01:19

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Epidermal stem cells (EpiSCs) are mainly located at the basal layer of the epidermis. These cells repair minor injuries of the skin and replace dead skin cells. However, EpiSCs’ cannot heal severe wounds such as major burns or those from diabetes or hereditary disorders. In such cases, culturing the epidermal stem cells from the patient is possible and has yielded successful treatment options, such as laboratory-grown skin grafts. These grafts are synthesized using a patient’s own...
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  11. Skin Rejuvenation Efficacy And Safety Evaluation Of Kaempferia Parviflora Standardized Extract (bg100) In Human 3d Skin Models And Clinical Trial

Skin Rejuvenation Efficacy and Safety Evaluation of Kaempferia parviflora Standardized Extract (BG100) in Human 3D Skin Models and Clinical Trial

Wannita Klinngam1, Phetploy Rungkamoltip1, Ratjika Wongwanakul1

  • 1National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency, Pathum Thani 12120, Thailand.

Biomolecules
|July 27, 2024

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View abstract on PubMed

Summary
This summary is machine-generated.

This study shows that Kaempferia parviflora extract (BG100) effectively rejuvenates skin by boosting collagen and hyaluronic acid, reducing oxidative stress, and minimizing DNA damage. It is a safe and natural anti-aging ingredient for cosmeceuticals.

Area of Science:

  • Dermatology and Cosmeceutical Science
  • Natural Product Chemistry
  • Cellular and Molecular Biology

Background:

  • Polymethoxyflavones from Kaempferia parviflora rhizomes exhibit anti-aging properties by inhibiting senescence and oxidative stress.
  • Kaempferia parviflora extract (BG100) is standardized and enriched with specific polymethoxyflavones.

Purpose of the Study:

  • To assess the anti-aging effects and safety of BG100 on photoaged skin.
  • To evaluate BG100's impact on skin rejuvenation, antioxidant properties, irritation, sensitization, and genotoxicity.

Main Methods:

  • Utilized photoaged human 3D full-thickness skin models to evaluate rejuvenation and antioxidant effects.
  • Assessed skin irritation and sensitization using reconstructed human epidermis and clinical trials.
  • Performed in vitro genotoxicity testing according to OECD guidelines.
Keywords:
3D skin modelKaempferia parviflora standardized extractanti-agingclinical trial

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Main Results:

  • BG100 significantly promoted collagen and hyaluronic acid production in skin models.
  • The extract demonstrated reduction in oxidative stress and minimization of DNA damage.
  • BG100 proved to be non-irritating and non-sensitizing, with negative results in genotoxicity tests.

Conclusions:

  • BG100 is a potent and safe natural anti-aging agent.
  • The extract effectively rejuvenates skin by enhancing cellular functions and structure.
  • BG100 is suitable for cosmeceutical and nutraceutical applications for skin rejuvenation.
polymethoxyflavones