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Updated: Jun 19, 2025

A Surgical Model of Heart Failure with Preserved Ejection Fraction in Tibetan Minipigs
Published on: February 18, 2022
Exploring Sirtuins: New Frontiers in Managing Heart Failure with Preserved Ejection Fraction
Ying Lu1, Yongnan Li2, Yixin Xie1
1Department of Cardiology, Lanzhou University Second Hospital, Lanzhou 730031, China.
Abstract:
With increasing research, the sirtuin (SIRT) protein family has become increasingly understood. Studies have demonstrated that SIRTs can aid in metabolism and affect various physiological processes, such as atherosclerosis, heart failure (HF), hypertension, type 2 diabetes, and other related disorders. Although the pathogenesis of HF with preserved ejection fraction (HFpEF) has not yet been clarified, SIRTs have a role in its development. Therefore, SIRTs may offer a fresh approach to the diagnosis, treatment, and prevention of HFpEF as a novel therapeutic intervention target.
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