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Related Experiment Video

Updated: Jun 19, 2025

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Design of Cecal Ligation and Puncture and Intranasal Infection Dual Model of Sepsis-Induced Immunosuppression

Published on: June 15, 2019

From Molecular Mechanisms to Clinical Therapy: Understanding Sepsis-Induced Multiple Organ Dysfunction.

Tijana Srdić¹, Siniša Đurašević¹, Iva Lakić¹

¹Faculty of Biology, University of Belgrade, 11000 Belgrade, Serbia.

International Journal of Molecular Sciences

|July 27, 2024

Summary

Sepsis causes organ damage through complex pathways. New research focuses on energy metabolism and gut health, showing promise in animal models for preventing sepsis-induced organ failure and mortality.

Keywords:

gut microbiota herbal extracts melatonin metformin multiple organ failure palmitoylethanolamide (PEA)sepsis sepsis treatment

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Last Updated: Jun 19, 2025

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Area of Science:

Pathophysiology
Molecular Mechanisms
Therapeutic Targets

Background:

Sepsis-induced multiple organ dysfunction involves inflammation, oxidative stress, and cellular damage.
Liver, cardiac, lung, and kidney dysfunction are primary causes of sepsis mortality.
Understanding sepsis mechanisms is crucial for developing effective treatments.

Purpose of the Study:

To review the complex pathophysiology of sepsis-induced multiple organ dysfunction.
To highlight emerging therapeutic strategies targeting energy metabolism and gut microbiota.
To discuss the potential of novel therapeutics in sepsis treatment.

Main Methods:

Review of current research on sepsis pathophysiology.
Analysis of novel therapeutic agents and their efficacy in sepsis models.
Focus on shifts in research from anti-inflammatory to metabolic and microbiota modulation.

Main Results:

Novel therapeutics like melatonin, metformin, and PEA show efficacy in sepsis models.
Modulating energy metabolism and gut microbiota demonstrates significant impact on preventing organ damage and mortality in animal models.
Current research trends shift towards energy metabolism and gut microbiota interventions.

Conclusions:

Sepsis pathophysiology is complex, involving multiple interacting pathways.
Targeting energy metabolism and gut microbiota represents a promising therapeutic avenue for sepsis.
Further clinical investigation is needed for novel sepsis treatments.