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Updated: Jun 19, 2025
10:51
The Synthesis, Characterization and Reactivity of a Series of Ruthenium N-triphosPh Complexes
Published on: April 10, 2015
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Ruthenium(II) Complex-Based Tetradentate Schiff Bases: Synthesis, Spectroscopic, Antioxidant, and Antibacterial
Bouchra Es-Sounni1, Kaoutar Harboul2, Ayoub Mouhib3
1Laboratory of Innovative Materials and Biotechnology of Naturel Resources, Faculty of Sciences, Moulay Ismail University, Meknes 50000, Morocco.
International Journal of Molecular Sciences
|July 27, 2024
Summary
Novel Ruthenium (II) complex-based salen Schiff bases were synthesized and characterized. These complexes demonstrate superior antioxidant and potent antibacterial activities against tested pathogens, outperforming positive controls.
Area of Science:
- Coordination Chemistry
- Materials Science
- Medicinal Chemistry
Background:
- Salen Schiff bases are versatile ligands in coordination chemistry.
- Ruthenium complexes are known for diverse biological activities.
- Developing new metal complexes with enhanced bioactivity is an ongoing research area.
Purpose of the Study:
- To synthesize and characterize novel Ruthenium (II) complex-based salen Schiff bases.
- To evaluate the antioxidant and antibacterial properties of the synthesized Ru(II) complexes.
- To establish structure-activity relationships for these new compounds.
Main Methods:
- Synthesis of Ruthenium (II) complex-based salen Schiff bases.
- Characterization using IR, UV-Vis, NMR, powder XRD, HRMS, DTA-TGA, and elemental analysis.
- Evaluation of antioxidant activity via DPPH, FRAP, and TAC assays; antibacterial activity via inhibition zone and MIC determination.
Main Results:
- Novel Ruthenium (II) complexes with octahedral geometries were successfully synthesized and characterized.
- The complexes exhibited significant antioxidant potential, surpassing the positive control.
- Promising antibacterial activity was observed against Bacillus subtilis and Proteus mirabilis, with specific MIC values reported for key complexes.
Conclusions:
- The synthesized Ruthenium (II) salen Schiff base complexes possess significant antioxidant and antibacterial properties.
- These novel complexes represent potential candidates for therapeutic applications.
- Further investigation into their mechanism of action and in vivo efficacy is warranted.
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