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Related Concept Videos

Serum Laboratory Studies, Stool Test, Breath Test01:30

Serum Laboratory Studies, Stool Test, Breath Test

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Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...
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  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. In Pursuit Of Novel Markers: Unraveling The Potential Of Mir-106, Cea And Ca 19-9 In Gastric Adenocarcinoma Diagnosis And Staging.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. In Pursuit Of Novel Markers: Unraveling The Potential Of Mir-106, Cea And Ca 19-9 In Gastric Adenocarcinoma Diagnosis And Staging.

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In Pursuit of Novel Markers: Unraveling the Potential of miR-106, CEA and CA 19-9 in Gastric Adenocarcinoma Diagnosis and Staging.

Adrian Boicean1, Ioana Boeras2,3, Sabrina Birsan1

  • 1Faculty of Medicine, Lucian Blaga University of Sibiu, 550169 Sibiu, Romania.

International Journal of Molecular Sciences
|July 27, 2024

View abstract on PubMed

Summary
This summary is machine-generated.

Classical tumor markers like CEA and CA 19-9, along with novel miR-106, were evaluated for gastric cancer diagnosis. CA 19-9 demonstrated superior predictive performance compared to miR-106.

Keywords:
biomarkerscarbohydrate antigen 19-9carcinoembryonic antigengastric cancer

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Area of Science:

  • Oncology
  • Biomarker Discovery
  • Gastroenterology

Background:

  • Gastric cancer is a leading global cause of cancer mortality, often diagnosed late.
  • Accurate diagnostic markers are crucial for improving gastric cancer prognosis.

Purpose of the Study:

  • To evaluate the diagnostic performance of classical markers (CEA, CA 19-9) and a novel marker (miR-106) for gastric adenocarcinoma.
  • To compare the predictive capabilities of these markers in gastric cancer diagnosis.

Main Methods:

  • Univariable and multivariable logistic regression analyses were performed.
  • Receiver operating characteristic (ROC) curves were constructed using predicted probabilities.
  • The diagnostic accuracy of CEA, CA 19-9, and miR-106 was assessed.
miRNA
screening

Main Results:

  • Elevated levels of miR-106, CEA, and CA 19-9 were predictive of a positive histopathological exam.
  • CA 19-9 showed the highest predictive value (AUC = 0.936) for gastric adenocarcinoma when considering age and gender.
  • Classical markers demonstrated superior performance over miR-106 in predicting gastric adenocarcinoma.

Conclusions:

  • Classical tumor markers, particularly CA 19-9, are effective predictors for gastric adenocarcinoma.
  • The novel marker miR-106 showed less diagnostic utility compared to established markers like CEA and CA 19-9.