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Updated: Jun 19, 2025
07:15
Robust Ligature-Induced Model of Murine Periodontitis for the Evaluation of Oral Neutrophils
Published on: January 21, 2020
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Bidirectional Association between Periodontitis and Thyroid Disease: A Scoping Review
Francesco Inchingolo1, Angelo Michele Inchingolo1, Alessio Danilo Inchingolo1
1Department of Interdisciplinary Medicine, University of Bari "Aldo Moro", 70124 Bari, Italy.
Summary
Periodontitis, a gum disease, is frequently found in patients with thyroid conditions. Treating periodontitis may improve thyroid health, suggesting a link between systemic inflammation and these diseases.
Area of Science:
- Oral Medicine
- Endocrinology
- Systemic Inflammation
Background:
- Periodontitis is a chronic inflammatory oral disease.
- Thyroid diseases encompass a range of conditions affecting thyroid hormone levels.
- Chronic inflammation from periodontitis is linked to systemic diseases, including thyroid disorders.
Purpose of the Study:
- To explore the probable causal relationship between periodontitis and thyroid disease.
- To investigate the epidemiological, pathogenetic, and treatment aspects of this association.
- To synthesize current evidence on the bidirectional link between these conditions.
Main Methods:
- A scoping review following PRISMA-ScR guidelines.
- Searched PubMed, Scopus, Web of Science, and Cochrane databases (January 2014 - January 2024).
- Used MESH terms 'periodontitis' and 'thyroid'; 20 articles were selected from 153 initial records.
Main Results:
- A high prevalence of periodontitis was observed in patients with thyroid disease, including thyroid cancer.
- Contributing factors include genetic elements, the oral microbiome, and proinflammatory cytokines.
- Periodontal treatment, such as scaling and root planing, demonstrated potential to improve thyroid parameters.
Conclusions:
- A bidirectional relationship between periodontitis and thyroid disease is suggested, primarily mediated by systemic inflammation.
- Further research, including randomized controlled trials, is warranted to confirm causality.
- Understanding this link may inform integrated treatment strategies for both conditions.
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