Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Obesity01:24

Obesity

418
The Body Mass Index (BMI) is a numerical value derived from a person's weight and height, used to categorize individuals into weight ranges. It is calculated using the formula: weight in kilograms divided by height in meters squared. Obesity is a health condition characterized by excessive accumulation of adipose tissue that poses health risks, often diagnosed with a BMI ≥ 30. This excess fat storage occurs when surplus dietary calories are converted into triglycerides and stored in...
418
Inflammation01:38

Inflammation

53.3K
Overview
53.3K
Psychoneuroimmunology: Diabetes and Cancer01:19

Psychoneuroimmunology: Diabetes and Cancer

27
Chronic stress has been linked to both the onset and progression of serious health conditions, including Type 2 diabetes and cancer. Type 2 diabetes, a widespread chronic illness, is closely associated with obesity and insulin resistance, both of which often worsen under stress. Studies indicate that men experiencing high levels of chronic stress face a 45% higher risk of developing diabetes compared to those with minimal stress. Stress triggers physiological responses that elevate blood...
27
Inflammatory Response01:28

Inflammatory Response

1.9K
An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...
1.9K
Hypodermis01:02

Hypodermis

4.3K
The hypodermis (the subcutaneous layer or superficial fascia) is present directly below the dermis. It connects the skin to the underlying fascia (fibrous tissue) of the bones and muscles. It is not strictly a part of the skin, although the border between the hypodermis and dermis can be difficult to distinguish. The hypodermis consists of well-vascularized, loose, areolar connective tissue and adipose tissue, which functions as a mode of fat storage and provides insulation and cushioning for...
4.3K
Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy01:30

Inflammatory Bowel Disease III: Diagnostic Studies and Management I-Nutritional Therapy

331
Various diagnostic tests are employed in the diagnostic process for Inflammatory Bowel Disease (IBD), particularly to differentiate between Crohn's disease and ulcerative colitis.
Diagnostic studies
A colonoscopy is the definitive screening test, distinguishing ulcerative colitis from other colon diseases with similar symptoms. During a colonoscopy test, inflamed mucosa with exudate ulcerations can be observed, and biopsies are taken to determine the histologic characteristics of the...
331

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Artificial Intelligence Applications in Implant Positioning, Dislocation Risk Prediction, and Surgical Indications in Orthopaedic Surgery.

Bioengineering (Basel, Switzerland)·2026
Same author

Robotic-Assisted Total Knee Arthroplasty: Current Evidence on PROMs, Functional Outcomes, Neuromotor Recovery, and Complications-A Narrative Review.

Medicina (Kaunas, Lithuania)·2026
Same author

Cutaneous Thermography in Arthropathies: Quantitative Imaging, Machine Learning, and Clinical Translation.

Journal of imaging·2026
Same author

A Systematic Review of the Clinical Impact of GLP-1 Receptor Agonists in Hidradenitis Suppurativa.

American journal of clinical dermatology·2026
Same author

A System in Motion: The Evolution of Orthopaedic Care in Romania.

The Journal of bone and joint surgery. American volume·2026
Same author

Diagnostic and prognostic biomarkers in heart failure and myeloproliferative neoplasms: clinical applications and risk scores - a narrative review.

Cardio-oncology (London, England)·2026

Related Experiment Video

Updated: Jun 18, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.2K

The Interplay between Obesity and Inflammation.

Ilinca Savulescu-Fiedler1,2, Razvan Mihalcea2, Serban Dragosloveanu3,4

  • 1Department of Internal Medicine, The "Carol Davila" University of Medicine and Pharmacy, 050474 Bucharest, Romania.

Life (Basel, Switzerland)
|July 27, 2024
PubMed
Summary

Obesity drives chronic inflammation, particularly through adipose tissue macrophages. Understanding these inflammatory pathways is key to developing new obesity treatments and managing related diseases.

Keywords:
adipocytesadipokinesadipose tissuecytokinesinflammationmacrophagesobesityweight loss

More Related Videos

Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.2K
Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

17.5K

Related Experiment Videos

Last Updated: Jun 18, 2025

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation
07:46

Isolation, Characterization, and Purification of Macrophages from Tissues Affected by Obesity-related Inflammation

Published on: April 3, 2017

25.2K
Isolation of Adipose Tissue Immune Cells
07:09

Isolation of Adipose Tissue Immune Cells

Published on: May 22, 2013

36.2K
Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry
07:32

Characterization of Immune Cells in Human Adipose Tissue by Using Flow Cytometry

Published on: March 6, 2018

17.5K

Area of Science:

  • Immunology
  • Metabolic Disorders
  • Cellular Biology

Background:

  • Obesity significantly impacts patient quality of life and elevates risks for tumors and immune-mediated disorders.
  • Chronic inflammation within adipose tissue, regulated by macrophages, is central to obesity's development and progression.
  • Macrophages in adipose tissue modulate pro- and anti-inflammatory cytokine secretion, influencing metabolic health.

Purpose of the Study:

  • To elucidate the role of inflammation and adipose tissue macrophages in obesity.
  • To identify signaling pathways in obesity-related inflammation for potential therapeutic interventions.
  • To understand how inflammation persists post-weight loss and its impact on macrophage phenotypes.

Main Methods:

  • Review of existing literature on obesity, inflammation, and adipose tissue biology.
  • Analysis of the role of macrophages in chronic inflammation associated with obesity.
  • Investigation of signaling pathways involved in adipose tissue inflammation.

Main Results:

  • Inflammation is a critical factor in obesity, with macrophages playing a central role in adipose tissue.
  • Specific signaling pathways within adipose tissue are implicated in obesity-related inflammation.
  • Persistent inflammation after weight loss may involve adaptive changes in macrophage phenotypes.

Conclusions:

  • Understanding the interplay between obesity and chronic inflammation is crucial for managing comorbidities.
  • Targeting adipose tissue inflammation and macrophage activity offers potential therapeutic strategies for obesity.
  • Further research into persistent inflammation and macrophage phenotype changes can inform future obesity treatments.