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Updated: Jun 18, 2025
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Understanding the Landscape of Multi-Cancer Detection Tests: The Current Data and Clinical Considerations
Cody E Cotner1,2, Elizabeth O'Donnell1,2,3
1Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
Abstract:
Multi-cancer detection (MCD) tests are blood-based assays that screen for multiple cancers concurrently and offer a promising approach to improve early cancer detection and screening uptake. To date, there have been two prospective interventional studies evaluating MCD tests as a screening tool in human subjects. No MCD tests are currently approved by the FDA, but there is one commercially available MCD test. Ongoing trials continue to assess the efficacy, safety, and cost implications of MCD tests. In this review, we discuss the performance of CancerSEEK and Galleri, two leading MCD platforms, and discuss the clinical consideration for the broader application of this new technology.
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